ZFP100 Inhibitors
Chemical inhibitors of ZFP100 function by modulating various signaling pathways that are crucial for the protein's activity. Chelerythrine and GF109203X, as protein kinase C (PKC) inhibitors, can inhibit the phosphorylation events that are essential for ZFP100's function. Since PKC is known to phosphorylate a wide range of substrates, these inhibitors can prevent the activation of ZFP100, leading to its functional inhibition. Similarly, the inhibitors PD 98059, U0126, and SL327 target the mitogen-activated protein kinase kinase (MEK), which is upstream of the extracellular signal-regulated kinase (ERK) pathway. Since ERK is often involved in the phosphorylation of transcription factors, these inhibitors can prevent ERK activation, which in turn can prevent ZFP100 from becoming fully functional.
In addition to these, LY294002 and wortmannin are phosphoinositide 3-kinase (PI3K) inhibitors. By inhibiting PI3K, these compounds can reduce the activity of the AKT signaling pathway, which can lead to the functional inhibition of ZFP100 if it relies on this pathway for activation. Y-27632, a Rho-associated protein kinase (ROCK) inhibitor, can affect actin cytoskeleton dynamics and potentially inhibit ZFP100 if its function is related to these cellular structures. Furthermore, SP600125 and SB203580 selectively inhibit the c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. These kinases are part of the MAPK signaling pathways, which can influence the activity of various proteins, including ZFP100. Lastly, PP2 inhibits Src family tyrosine kinases, which can modulate numerous signaling pathways, while KN93 targets calcium/calmodulin-dependent protein kinase II (CaMKII). If ZFP100's activity is modulated by calcium signaling or Src kinase-mediated pathways, then inhibition by KN93 and PP2 can lead to its functional inhibition.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC). As ZFP100 activity can be modulated by phosphorylation, inhibition of PKC by chelerythrine can lead to reduced phosphorylation of ZFP100, thus inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a specific inhibitor of mitogen-activated protein kinase kinase (MEK), a kinase upstream of the extracellular signal-regulated kinase (ERK) pathway. ZFP100, if regulated by the ERK pathway, would be functionally inhibited by the blockade of this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinases (PI3K) inhibitor. PI3K is part of the AKT signaling pathway, which can influence the activity of various zinc finger proteins. By inhibiting PI3K, LY294002 can lead to a functional inhibition of ZFP100. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of the Rho-associated protein kinase (ROCK). If ZFP100 function is regulated by actin cytoskeleton dynamics, which are controlled by ROCK, its inhibition by Y-27632 may result in functional inhibition of ZFP100. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). JNK pathway can regulate the activity of various transcription factors and zinc finger proteins. Inhibition of JNK could thus lead to the functional inhibition of ZFP100. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, similar to PD 98059. It prevents the activation of ERK, which may be involved in the phosphorylation and regulation of transcription factors like ZFP100, thereby inhibiting its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor. The p38 pathway is another MAPK pathway that can regulate transcription factors. Inhibition of p38 MAP kinase may inhibit the functional activity of ZFP100. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K like LY294002. It can functionally inhibit ZFP100 by reducing PI3K/AKT pathway activity, which may influence the phosphorylation state and function of ZFP100. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. Src kinases can modulate the activity of various signaling pathways, potentially affecting the function of transcription factors like ZFP100. Inhibition of Src could lead to the functional inhibition of ZFP100. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN93 is an inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). If ZFP100 is regulated by calcium signaling, inhibition of CaMKII by KN93 could lead to a functional inhibition of ZFP100. | ||||||