ZDHHC22 Activators

ZDHHC22, or Zinc Finger DHHC-Type Palmitoyltransferase 22, is a protein encoded by the ZDHHC22 gene in humans. Belonging to the DHHC (Asp-His-His-Cys) family of proteins, ZDHHC22 is categorized as a palmitoyltransferase, an enzyme that adds a palmitate (a type of fatty acid) to other proteins in a process known as palmitoylation.Palmitoylation is a reversible post-translational modification that increases the hydrophobicity of proteins, enhancing their association with cellular membranes. This modification can affect the protein's localization, stability, and interactions, thereby influencing its function and the overall cellular processes.

ZDHHC22, like other DHHC proteins, contains a conserved DHHC domain, which is essential for its enzymatic activity. This domain includes a cysteine-rich region that coordinates a zinc ion, necessary for the transfer of the palmitate group to target proteins.Dysregulation of palmitoylation processes can lead to various diseases, including neurological disorders and cancer, highlighting the importance of enzymes like ZDHHC22.In summary, ZDHHC22 is a palmitoyltransferase involved in the post-translational modification of proteins. It plays a role in regulating protein function by enhancing their association with cellular membranes.