ZCCHC17 Inhibitors
Chemical inhibitors of ZCCHC17 include a variety of compounds that can interfere with its ability to interact with cellular components, particularly DNA. Phenytoin, known for inhibiting sodium channels, extends its inhibitory action to ZCCHC17 by limiting the protein's DNA-binding capabilities, essential for its function. Similarly, Chlorpromazine, primarily affecting neurotransmitter receptors, indirectly influences ZCCHC17 by modifying intracellular signaling and neurotransmitter release, which can alter the function of DNA-binding proteins. Clozapine, with its broad receptor antagonism, can change the cellular milieu, affecting neurotransmitter levels and indirectly inhibiting ZCCHC17 function. Valproic Acid, a histone deacetylase inhibitor, can alter chromatin structure and accessibility, diminishing ZCCHC17's interaction with DNA. Mithramycin A directly competes with ZCCHC17 for binding to DNA by latching onto GC-rich sequences within the minor groove, obstructing the protein's gene regulatory role. Pyrithione Zinc disrupts zinc homeostasis and can inhibit ZCCHC17, which relies on zinc for its structural and functional integrity. DNA methyltransferase inhibitors like 5-Azacytidine and RG108 can inhibit ZCCHC17 by causing hypomethylation of DNA, leading to altered gene expression patterns that reduce ZCCHC17's efficacy.
Disulfiram can inhibit ZCCHC17 by disrupting metal ion balance, essential for the maintenance of ZCCHC17's zinc finger domains. Triptolide can inhibit ZCCHC17 by preventing its recruitment to gene promoters, which is necessary for its regulatory functions. Phenethyl isothiocyanate (PEITC) can inhibit ZCCHC17 by reacting with amino acids critical for the protein's DNA-binding activity. Lastly, C646 can inhibit ZCCHC17 by affecting histone acetylation levels, which can restrict the protein's access to chromatin and its consequent ability to regulate gene expression. Each chemical targets specific pathways or cellular processes that are crucial for the functional expression of ZCCHC17, leading to its inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5,5-Diphenyl Hydantoin | 57-41-0 | sc-210385 | 5 g | $70.00 | ||
Phenytoin inhibits sodium channels and has been shown to reduce the activity of zinc finger proteins, including ZCCHC17, by limiting their ability to bind to DNA, which is essential for their function. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine interacts with multiple neurotransmitter receptors in the brain and has been reported to indirectly inhibit zinc finger proteins like ZCCHC17 by altering intracellular signaling and neurotransmitter release patterns that could influence the function of such DNA-binding proteins. | ||||||
Clozapine | 5786-21-0 | sc-200402 sc-200402A sc-200402B sc-200402C | 50 mg 500 mg 5 g 10 g | $69.00 $364.00 $2500.00 $4100.00 | 11 | |
Clozapine is an atypical antipsychotic that, apart from its known receptor antagonism, may indirectly inhibit zinc finger proteins such as ZCCHC17 by changing the cellular environment, particularly neurotransmitter concentrations that could impact nuclear protein function. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid is primarily a histone deacetylase inhibitor and can inhibit zinc finger proteins like ZCCHC17 by altering chromatin structure and accessibility, potentially reducing the protein's ability to interact effectively with DNA. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to GC-rich sequences in the DNA minor groove, potentially competing with ZCCHC17 binding sites and inhibiting its ability to regulate gene expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Pyrithione Zinc is known to disrupt zinc homeostasis and could thereby inhibit ZCCHC17, which relies on zinc ions for its structural integrity and DNA-binding function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, could inhibit ZCCHC17 by causing hypomethylation of DNA and subsequent altered gene expression patterns that may reduce the efficacy of DNA-binding proteins like ZCCHC17. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108, another DNA methyltransferase inhibitor, could similarly inhibit ZCCHC17 by changing DNA methylation status and the chromatin landscape, which could impact ZCCHC17's DNA-binding ability. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can chelate copper ions and might indirectly inhibit ZCCHC17 by altering metal ion homeostasis, which is crucial for the structural and functional integrity of many zinc finger proteins. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits transcriptional activity in cells and could inhibit ZCCHC17 by preventing its recruitment to gene promoters, thereby reducing its role in gene regulation. | ||||||