ZBTB44 Inhibitors
Chemical inhibitors of ZBTB44 can exert their effects through various mechanisms, impacting the protein's role in cellular functions. Palbociclib and its alternative name PD0332991, both CDK4/6 inhibitors, can inhibit ZBTB44 by preventing the phosphorylation of the retinoblastoma protein. This halts the cell cycle progression from G1 to S phase, which is a crucial point at which ZBTB44 may exert its influence on cellular proliferation. Similarly, MLN4924 targets a different aspect of cell cycle regulation by inhibiting the NEDD8-activating enzyme, which is essential for the neddylation process. This disrupts the function of Cullin-RING E3 ubiquitin ligases, enzymes that are responsible for the ubiquitination and degradation of proteins that regulate cell growth and cycle progression, thereby affecting the pathways where ZBTB44 may be active.
Another layer of regulation is provided by modifying the epigenetic landscape, which is where Trichostatin A, A-366, and C646 come into play. Trichostatin A, a histone deacetylase inhibitor, can alter chromatin structure and thus suppress gene expression patterns crucial for ZBTB44's role in cell proliferation and survival. In a similar vein, A-366 inhibits G9a/GLP histone methyltransferase activity, thereby affecting histone methylation and altering gene expression patterns. C646, by selectively inhibiting p300/CPB histone acetyltransferase, blocks histone acetylation, further influencing the transcription of genes regulated by ZBTB44. JQ1 targets the recognition of acetylated lysines by BET bromodomain proteins, displacing them from chromatin and affecting gene expression involved in cell cycle and DNA repair, which are processes where ZBTB44 could be implicated. YK-4-279 inhibits ETV1, part of the ETS transcription factor family, thus indirectly affecting the gene expression programs regulated by ZBTB44, particularly those linked to cell cycle and apoptosis. Lastly, ABT-737, by inhibiting Bcl-2 family proteins, promotes apoptosis, opposing the survival signals that may be regulated by ZBTB44.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a CDK4/6 inhibitor that can inhibit ZBTB44 by preventing phosphorylation of retinoblastoma (Rb) protein, which is necessary for cell cycle progression from G1 to S phase. The inhibition of CDK4/6 activity can reduce the cell proliferation that ZBTB44 may be promoting in cells where it is overexpressed. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 inhibits the NEDD8-activating enzyme necessary for neddylation, which can inhibit ZBTB44 by impairing the neddylation-dependent activation of Cullin-RING E3 ubiquitin ligases (CRLs). CRLs are responsible for the ubiquitination and subsequent degradation of various proteins that regulate cell cycle and growth, potentially involving ZBTB44-regulated pathways. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can inhibit ZBTB44 indirectly by preventing the degradation of IκB, an inhibitor of NF-κB. The accumulation of IκB leads to reduced NF-κB activity. Since NF-κB can regulate the expression of genes involved in cell survival and proliferation, inhibition of this pathway can reduce the functions regulated by ZBTB44. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can inhibit ZBTB44 by modifying chromatin structure, thereby affecting the transcription of genes that ZBTB44 may regulate. This can lead to the suppression of gene expression patterns that are essential for ZBTB44's role in cell proliferation and survival. | ||||||
A-366 | 1527503-11-2 | sc-507495 | 10 mg | $195.00 | ||
A-366 is a selective G9a/GLP histone methyltransferase inhibitor that can inhibit ZBTB44 by altering histone methylation, thereby affecting the transcription of genes that ZBTB44 may regulate. This can lead to the alteration of gene expression patterns that are essential for ZBTB44's role in cell proliferation and differentiation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a BET bromodomain inhibitor that can inhibit ZBTB44 by displacing BET bromodomain proteins from chromatin, thereby affecting the expression of genes involved in cell cycle progression, apoptosis, and DNA repair. Since ZBTB44 has been implicated in gene transcription regulation, JQ1 can indirectly inhibit ZBTB44's regulatory functions. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a selective p300/CPB histone acetyltransferase inhibitor that can inhibit ZBTB44 by blocking the acetylation of histone proteins, thus affecting the transcription of genes that ZBTB44 may regulate. This can lead to alterations in gene expression patterns crucial for ZBTB44's role in cell cycle regulation and cellular growth. | ||||||
ABT 737 | 852808-04-9 | sc-207242 | 2.5 mg | $200.00 | 54 | |
ABT-737 is a Bcl-2 family protein inhibitor that can inhibit ZBTB44 indirectly by promoting apoptosis. Since ZBTB44 may influence gene expression programs that promote cell survival, ABT-737-induced apoptosis can oppose these survival signals, thereby inhibiting the pro-survival effects that might be regulated by ZBTB44. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that can inhibit ZBTB44 by blocking the MAPK/ERK pathway, which is involved in cell cycle control and differentiation. As ZBTB44 may regulate genes within this pathway, inhibition of MEK prevents the pathway's downstream signaling, which can suppress the transcriptional programs ZBTB44 is involved with, leading to inhibition of cell proliferation and survival. | ||||||