ZBTB40 Inhibitors
ZBTB40 Inhibitors are a series of chemical compounds that attenuate the transcriptional repression activity of ZBTB40 through various epigenetic and proteostatic mechanisms. Histone deacetylase inhibitors such as Trichostatin A and Suberoylanilide Hydroxamic Acid disrupt the epigenetic landscape by increasing histone acetylation, which interferes with ZBTB40's ability to bind chromatin and enact its regulatory functions. This mechanism is shared by other HDAC inhibitors like MS-275 and Mocetinostat, which similarly lead to a less conducive environment for ZBTB40's repressor activity. Proteasome inhibitors, including MG-132 and Bortezomib, thwart the degradation of ubiquitinated proteins, leading to cellular proteostatic stress that couldnegatively affect ZBTB40's function by sequestering the protein away from its transcriptional targets. Additionally, the DNA methyltransferase inhibitor 5-Azacytidine and the G9a/GLP inhibitor UNC0638 modulate the DNA methylation landscape, which could disrupt ZBTB40's interaction with methylated genomic regions, thereby diminishing its capacity to suppress gene expression.
The chemical compound JQ1, targeting the BET bromodomains, is theorized to displace these proteins from chromatin, which may indirectly result in reduced ZBTB40 functionality by altering its genomic binding profile. Quercetin, known for its kinase inhibition, could interfere with ZBTB40-mediated transcriptional networks by disrupting kinase signaling pathways. Disulfiram, with its broad inhibitory actions, could impede ZBTB40's ability to maintain a transcriptionally repressive chromatin environment. Additionally, the selective DOT1L inhibitor PF-06726304, could impair ZBTB40's interaction with chromatin by affecting H3K79 methylation, a mark associated with active transcription. Collectively, these inhibitors utilize diverse biochemical routes to diminish the functional activity of ZBTB40, doing so by directly or indirectly impacting the molecular processes that govern its transcriptional repression capabilities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to hyperacetylation of histones, thereby affecting chromatin structure and gene expression. By altering the acetylation status of histones, Trichostatin A may decrease ZBTB40 binding to chromatin, diminishing its transcriptional repressor activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. Accumulation of these proteins can lead to altered signaling pathways, potentially reducing the capacity of ZBTB40 to regulate gene expression due to proteostatic stress. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that induces DNA demethylation, potentially disrupting the recruitment of ZBTB40 to methylated DNA regions and its ability to repress transcription. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a small molecule inhibitor of the BET family of bromodomain proteins. By displacing BET proteins from chromatin, JQ1 may indirectly decrease the recruitment of ZBTB40 to its target genes, leading to diminished transcriptional repression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid is another histone deacetylase inhibitor, that can lead to increased histone acetylation, potentially interfering with ZBTB40's ability to bind to chromatin and execute its repressor functions. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. It could indirectly affect ZBTB40 function by causing the accumulation of misfolded proteins, which may sequester ZBTB40, reducing its transcriptional repression activity. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
UNC0638 is a selective inhibitor of G9a and GLP histone methyltransferases. By inhibiting these enzymes, UNC0638 may reduce histone methylation, potentially altering the binding affinity of ZBTB40 for chromatin and diminishing its repressive activity on gene expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with numerous biological effects, including the inhibition of PI3K and other kinases. By modulating kinase activity, Quercetin may indirectly impact ZBTB40's ability to modulate transcriptional networks, leading to decreased repression of target genes. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is a selective inhibitor of class I histone deacetylases. Diminished HDAC activity can lead to less effective recruitment of ZBTB40 to its target gene promoters due to changes in histone acetylation, thus impairing its repressive function. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram is an inhibitor of aldehyde dehydrogenase (ALDH) and can affect various cellular pathways. Through its pleiotropic effects, Disulfiram may diminish the ability of ZBTB40 to maintain chromatin in a repressive state, indirectly decreasing its transcriptional regulatory function. | ||||||