WDR42A Inhibitors
The inhibitors of DCAF8 (WDR42A) represent a diverse array of chemical compounds that indirectly diminish the protein's activity by targeting various cellular processes and signaling pathways. Rapamycin, through its inhibition of the mTORC1 complex, may disrupt the protein ubiquitination and degradation pathways essential for DCAF8 function, leading to a decrease in the availability of proteins necessary for DCAF8-mediated ubiquitination. Proteasome inhibitors like Bortezomib and MG-132 directly prevent the degradation of ubiquitinated proteins, potentially causing a feedback inhibition that could impair the normal function of DCAF8 in the ubiquitin-proteasome pathway. Similarly, LY 294002 and Wortmannin, as PI3K inhibitors, could indirectly affect DCAF8 by hindering phosphorylation events crucial for the ubiquitination signaling processes in which DCAF8 is involved.
In addition to these, the HDAC inhibitors Trichostatin A and Sodium Butyrate could alter gene expression and modify the ubiquitination pathway, indirectly affecting DCAF8's role. Chloroquine's inhibition of lysosomal activity and 3-Methyladenine(3-MA)'s prevention of autophagosome formation both could disrupt the degradation routes that DCAF8 is associated with, potentially leading to a decrease in its function. Curcumin, by interfering with the NF-κB pathway, and kinase inhibitors like PD 98059 and SB 203580, which target the MAPK/ERK and p38 MAPK pathways respectively, could lead to a reduced phosphorylation of proteins involved in ubiquitination. This reduction could impinge upon the functional activity of DCAF8, showcasing the intricate network of cellular pathways that these inhibitors influence to ultimately diminish DCAF8's role in protein ubiquitination and degradation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that decreases the activity of the mTORC1 complex. WDR42A, as part of the DCAF8 protein complex, has been implicated in protein ubiquitination and degradation pathways. By inhibiting mTORC1, rapamycin may diminish the availability of key proteins that WDR42A requires for its functional ubiquitination processes. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. Since WDR42A is associated with protein ubiquitination, the inhibition of proteasome activity can lead to the accumulation of substrates and potentially disrupt WDR42A's normal function in ubiquitin-proteasome pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is another proteasome inhibitor with a mechanism similar to bortezomib. It would lead to an accumulation of ubiquitinated proteins, which might indirectly diminish WDR42A's role in tagging proteins for degradation, due to feedback inhibition resulting from elevated levels of ubiquitinated proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 is a PI3K inhibitor that impedes the PI3K/AKT pathway. Inhibition of this pathway could reduce phosphorylation events that are necessary for the optimal function of DCAF8 and associated proteins like WDR42A, leading to decreased activity in ubiquitination signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor with a similar mechanism to LY294002. By diminishing the PI3K/AKT pathway, it would indirectly decrease WDR42A function by impeding necessary phosphorylation events, hence affecting the protein's role in ubiquitination signaling. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor that alters chromatin structure and gene expression. By changing the expression patterns of proteins involved in the ubiquitination pathway, Trichostatin A could indirectly diminish WDR42A's function in tagging proteins for degradation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, another HDAC inhibitor, works similarly to Trichostatin A by altering gene expression and could affect proteins that interact with WDR42A, indirectly diminishing its ubiquitination functionality. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to inhibit lysosomal activity by raising the internal pH. Since WDR42A is implicated in ubiquitination, which targets proteins to lysosomes for degradation, inhibition of lysosomal function could indirectly diminish WDR42A's functional role in the degradation pathway. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine (3-MA) is an autophagy inhibitor that prevents the formation of autophagosomes. Since WDR42A is involved in ubiquitination, which can tag proteins for autophagic degradation, inhibition of autophagy could indirectly diminish WDR42A's role in this cellular degradation process. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to interfere with multiple cellular signaling pathways, including the inhibition of NF-κB activation. As NF-κB can regulate the expression of various proteins, including those involved in ubiquitination, curcumin might indirectly diminish WDR42A's function by altering the expression of its potential substrates. | ||||||