WDR17 Inhibitors
WDR17 inhibitors encompass a diverse array of chemical compounds that interfere with various signaling pathways and cellular processes, ultimately leading to the diminished functional activity of WDR17. Staurosporine, by inhibiting protein kinases non-selectively, can disrupt the ciliary function that WDR17 is associated with, thereby reducing its activity. Similarly, Cyclopamine's role as a Hedgehog pathway inhibitor and Rapamycin's inhibition of mTOR can both lead to decreased ciliary function, where WDR17 plays a role, by affecting the pathway and ciliogenesis, respectively. Chlorpromazine, through its antagonistic effects on calmodulin, can impair calcium signaling, thus indirectly impacting WDR17's ciliary function. Perhexiline's influence on fatty acid metabolism and Brefeldin A's disruption of protein trafficking both pose indirect threats to WDR17's role in ciliary operations, while Thapsigargin's effect on calcium homeostasis can further complicate the protein's activity.
The integrity of ciliary structures, essential for WDR17's function, can be compromised by compounds like Nocodazole and Colchicine, which target microtubule polymerization, leading to potential reductions in WDR17 activity. Lithium chloride, by inhibiting GSK-3and thus modulating Wnt signaling, can affect WDR17's functional involvement within ciliary processes. The cholesterol transport inhibitor U 18666A can alter lipid raft dynamics, which are crucial for proper ciliary signaling involving WDR17, hence decreasing the protein's activity. Lastly, Zoledronic acid, by hindering farnesyl pyrophosphate synthase, impacts protein prenylation and localization, potentially leading to a diminished functionality of WDR17 within ciliary structures. These inhibitors, through their targeted effects on cellular structures and signaling pathways, collectively contribute to the reduction of WDR17's functional activity without affecting its expression levels or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent non-selective inhibitor of protein kinases. WDR17 is implicated in ciliary function, and the inhibition of certain kinases by Staurosporine could indirectly lead to ciliary dysfunction, thereby diminishing WDR17's functional activity. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
A Hedgehog signaling pathway inhibitor. WDR17 may play a role in this pathway by its association with primary cilia, so Cyclopamine inhibition of Hedgehog signaling could reduce the functional activity of WDR17 in the pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can impede the mTOR signaling pathway. Since mTOR can regulate ciliogenesis, Rapamycin may indirectly lead to a decrease in WDR17 activity by inhibiting cilia formation where WDR17 is involved. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
A calmodulin antagonist that can disrupt calcium signaling. WDR17 is associated with calcium-dependent processes in ciliary function, and Chlorpromazine could indirectly diminish WDR17 activity by altering calcium signaling. | ||||||
rac Perhexiline Maleate | 6724-53-4 | sc-460183 | 10 mg | $184.00 | ||
A carnitine palmitoyltransferase-1 inhibitor. By altering fatty acid metabolism, Perhexiline can affect the energy balance within cells, potentially leading to reduced ciliary function where WDR17 is involved. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
An inhibitor of ADP-ribosylation factor (ARF), which disrupts protein trafficking from the ER to the Golgi. WDR17 may be involved in protein trafficking associated with ciliary function, so Brefeldin A could reduce WDR17 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase (SERCA), disrupting calcium homeostasis. WDR17 activity could be indirectly diminished due to the role of calcium signaling in ciliary function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
An agent that disrupts microtubule polymerization. Since WDR17 is linked with ciliary microtubules, Nocodazole could lead to a decrease in WDR17 activity by impairing ciliary structure and function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
An inhibitor of microtubule polymerization. As WDR17 is associated with the ciliary microtubules, Colchicine could indirectly diminish WDR17 activity by disrupting the ciliary structure. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
An inhibitor of GSK-3, leading to altered Wnt signaling. Since WDR17 may be involved in Wnt signaling through ciliary mechanisms, Lithium chloride could indirectly reduce WDR17's functional activity. | ||||||