WBP5 Inhibitors
WBP5 inhibitors encompass a range of compounds that act on various signaling pathways and cellular processes to exert their inhibitory effects on WBP5 function. Kinase inhibitors play a pivotal role by interfering with phosphorylation events that are crucial for the activation and function of WBP5. By preventing kinase-mediated phosphorylation, these inhibitors ensure that WBP5 remains in an inactive state, unable to perform its role within the cell. Another subset of these inhibitors targets the PI3K/AKT/mTOR signaling axis, a critical pathway for cell proliferation and survival. By impeding the PI3K enzymes, these compounds attenuate AKT phosphorylation and activity, leading to a reduction in downstream signaling events that would otherwise contribute to the functional activity of WBP5. The mTOR pathway, known for its regulation of cell growth, is also a target, as inhibition here may diminish the expression of proteins that interact with WBP5, thereby indirectly decreasing WBP5 activity.
Further extending the arsenal of WBP5 inhibitors are compounds that inhibit MEK and subsequently the ERK pathway, which could be crucial for the functional activity of WBP5. By halting the signal transduction normally propagated through ERK, these inhibitors may lead to a reduction in WBP5 activity. Additionally, p38 MAP kinase inhibitors disrupt cellular stress response pathways, potentially affecting WBP5 activity if it is engaged in these pathways. Proteasome inhibitors introduce another mechanism of inhibition, leading to the accumulation of proteins within the cell, which may interfere with the protein turnover and interaction networks essential for the function of WBP5.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that disrupts signal transduction pathways involving kinases, leading to the inhibition of WBP5 by preventing its phosphorylation and subsequent activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of phosphoinositide 3-kinases (PI3K), which indirectly reduces the activation of downstream targets such as AKT that may be required for the full functional activity of WBP5. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An inhibitor of the mTOR pathway, which is involved in cell growth and proliferation. Inhibition of this pathway may result in downregulation of factors that interact with WBP5, diminishing its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of mitogen-activated protein kinase kinase (MEK), which acts upstream of the ERK pathway. By inhibiting MEK, the downstream activation of ERK is reduced, potentially diminishing the functional activity of WBP5 if ERK pathway involvement is required. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A selective inhibitor of p38 MAP kinase, which is involved in stress responses. Inhibition of p38 MAP kinase can alter the cellular response to stress, potentially reducing the activity of WBP5 if it is involved in such pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent inhibitor of PI3K, leading to a decrease in AKT phosphorylation and activity, which could indirectly reduce the activity of WBP5 through lessened downstream signaling. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An inhibitor of MEK1/2, preventing the activation of the ERK pathway. By blocking this pathway, the inhibitor could reduce the downstream signaling that may be necessary for WBP5 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which plays a role in cellular stress and apoptosis. Inhibiting JNK could potentially decrease the functional activity of WBP5 if it is part of JNK-mediated signaling. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that leads to the accumulation of ubiquitinated proteins. This can indirectly lead to the inhibition of WBP5 by affecting protein turnover and potentially disrupting interactions with other proteins. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An inhibitor of histone deacetylases (HDACs), which leads to changes in chromatin structure and gene expression. This may indirectly inhibit WBP5 by altering the expression of genes that encode proteins interacting with WBP5. | ||||||