WAVE4 Inhibitors
WAVE4 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of the WAVE4 protein, a member of the WAVE (Wiskott-Aldrich Syndrome Protein Family Verprolin-homologous) family. These proteins are known for their crucial role in regulating actin cytoskeleton dynamics, which are essential for various cellular processes such as cell movement, shape maintenance, and intracellular transport. WAVE4, like other WAVE proteins, is involved in the activation of the Arp2/3 complex, a major component responsible for the nucleation of new actin filaments. By inhibiting WAVE4, these compounds interfere with the protein's ability to regulate actin polymerization and the formation of branched actin networks, leading to alterations in the cellular architecture and motility that depend on these processes.
The mechanism of action for WAVE4 inhibitors typically involves binding to functional regions of the WAVE4 protein that are essential for its interaction with other regulatory proteins or with actin-nucleating complexes like Arp2/3. This inhibition blocks the ability of WAVE4 to activate actin polymerization, thus impairing processes that require dynamic remodeling of the actin cytoskeleton, such as cell migration and vesicle trafficking. Researchers use WAVE4 inhibitors to study the specific role of WAVE4 in the regulation of cytoskeletal dynamics and to explore how its inhibition impacts broader cellular functions, such as intracellular signaling and structural integrity. By targeting WAVE4, these inhibitors provide valuable tools for understanding the complex mechanisms underlying cytoskeleton organization and how the disruption of actin regulation can affect various physiological processes across different cell types.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is known to inhibit histone deacetylase, leading to a more acetylated and open chromatin state that could potentially downregulate WAVE4 by disrupting the specific histone code required for its gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could decrease methylation levels on the WAVE4 gene promoter, potentially leading to a reduction in WAVE4 mRNA synthesis and subsequent protein levels. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 targets BET bromodomains, which could lead to the dissociation of these proteins from chromatin on the WAVE4 locus, possibly resulting in decreased transcriptional activity of the WAVE4 gene. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
As a specific inhibitor of MEK1/2, U0126 could downregulate ERK pathway signaling, which may be necessary for the transcriptional activation of WAVE4, thereby leading to reduced levels of WAVE4 protein. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002, by inhibiting PI3K, could result in lowered AKT phosphorylation and activity, which may be critical for the transcriptional upregulation of WAVE4, leading to a decrease in its expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to mTORC1, inhibiting its activity, which is often involved in the transcriptional control of various genes; this action could lead to decreased synthesis of WAVE4. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
As a p38 MAPK inhibitor, SB 203580 could downregulate the p38 pathway, which may play a role in the stress-induced transcriptional upregulation of WAVE4, thereby decreasing its expression levels. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
Inhibiting JNK with SP600125 could downregulate the transcription factors activated by JNK that are potentially involved in the transcriptional initiation of WAVE4, consequently reducing WAVE4 expression. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits ROCK kinase activity, which could downregulate downstream transcriptional processes necessary for the expression of WAVE4, resulting in decreased levels of WAVE4 mRNA and protein. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Targeting MEK with PD 98059 may lead to reduced ERK activation, which could be essential for the transcriptional induction of WAVE4, thus decreasing its overall expression in the cell. | ||||||