WAC Inhibitors
WAC inhibitors denote a class of chemical compounds that target the WW domain-containing adaptor protein with coiled-coil (WAC), which plays a significant role in various cellular processes. WAC, as a multifunctional protein, is involved in the regulation of gene transcription and is known to interact with diverse proteins within the cell. The inhibition of WAC can therefore influence the activity of its protein partners and alter the transcriptional landscape within the cell. The inhibitors in this class are designed to bind to the WAC protein selectively, impeding its normal function by blocking its active sites or interfering with its capacity to engage with other proteins. The specificity of WAC inhibitors is crucial, as it determines their selectivity and ability to modulate the function of the WAC protein without affecting other proteins with similar domains or functions.
Chemically, WAC inhibitors may consist of a range of small molecules, each with a structure tailored to fit the binding regions of the WAC protein. The design of these molecules is often informed by the detailed structural knowledge of WAC, including the shape, charge distribution, and hydrophobic or hydrophilic nature of its interaction sites. The inhibitors might mimic the natural substrates or ligands of the WAC protein, competing for binding sites or altering the protein's conformation. Advanced techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and computational modeling are typically employed to understand the interaction between WAC inhibitors and their target protein at the molecular level, paving the way for the refinement of these compounds to achieve high potency and selectivity. The overall goal in developing WAC inhibitors is to provide precise modulation of protein-protein interactions involving WAC, thereby affecting the downstream cellular activities controlled by these interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. Inhibition of histone deacetylase can result in altered transcription and decreased expression of numerous genes, including potentially the WAC gene, leading to reduced WAC protein levels. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA, like Trichostatin A, is a histone deacetylase inhibitor that can suppress the expression of genes by altering chromatin structure. This can indirectly lead to decreased levels of the WAC protein through reduced transcription. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to the accumulation of polyubiquitinated proteins and disrupts their degradation. If WAC is subject to proteasomal degradation, MG-132 could lead to an aberrant increase in WAC, potentially triggering autoregulatory mechanisms that inhibit new WAC protein synthesis. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is another proteasome inhibitor that functions similarly to MG-132. By preventing the degradation of proteins, it can indirectly result in decreased synthesis of WAC due to feedback inhibition mechanisms. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is an autophagy inhibitor that can lead to the accumulation of cellular debris and dysfunctional organelles. If WAC is involved in autophagic processes, inhibition of autophagy could decrease WAC functional activity by preventing its normal turnover or recycling. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the vacuolar type H+-ATPase (V-ATPase) and can inhibit autophagy by preventing the acidification of lysosomes. If WAC is implicated in lysosomal degradation pathways, bafilomycin A1 could indirectly inhibit WAC activity. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin is an inhibitor of ATP synthase, which can lead to decreased cellular ATP levels. If WAC activity is ATP-dependent, oligomycin could indirectly inhibit WAC function by reducing available ATP. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase, which prevents mRNA synthesis. This would reduce the transcription of all genes, including potentially the gene for WAC, leading to decreased WAC protein levels. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein elongation. This would lead to a general decrease in protein synthesis, potentially affecting WAC protein levels as well. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that can downregulate protein synthesis and cell growth. If WAC protein synthesis is dependent on mTOR signaling, rapamycin could indirectly decrease WAC protein levels. | ||||||