Date published: 2025-11-24

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VR1 Inhibitors

VR1 inhibitors belong to a chemical class that specifically targets the VR1 receptor, also known as the vanilloid receptor 1. These inhibitors are designed to modulate the activity of this receptor, which is primarily found on sensory nerve endings and plays a crucial role in the transmission of pain signals. The VR1 receptor is a subtype of the transient receptor potential (TRP) family of ion channels and is known for its sensitivity to various chemical and physical stimuli, such as capsaicin (the active component in chili peppers) and heat. VR1 inhibitors act by binding to specific binding sites on the receptor, thereby preventing its activation and subsequent downstream signaling. This inhibitory effect leads to a reduction in the transmission of pain signals, which may have implications in various physiological and pathological processes. By targeting the VR1 receptor, these inhibitors offer an avenue for the modulation of pain perception and related sensory responses.

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Items 11 to 13 of 13 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

JYL-1413

735331-54-1sc-202192
sc-202192A
1 mg
5 mg
$200.00
$400.00
(0)

JYL-1413 is a distinctive VR1 receptor modulator, notable for its unique structural features that facilitate selective interactions with the receptor. Its acyl halide functionality promotes efficient nucleophilic attack, leading to swift acylation processes. This compound's ability to form stable complexes with receptor sites alters conformational states, influencing ion channel activity and subsequent signal transduction. Its reactivity profile underscores its potential for fine-tuning molecular interactions within biological systems.

SU-154

681810-30-0sc-203285
sc-203285A
1 mg
5 mg
$200.00
$400.00
(0)

SU-154 is an intriguing VR1 receptor modulator characterized by its unique reactivity as an acid halide. Its electrophilic nature enhances the formation of transient intermediates, allowing for rapid and selective acylation of target sites. The compound exhibits distinct steric and electronic properties that influence its interaction dynamics, promoting specific conformational changes in receptor proteins. This behavior facilitates nuanced modulation of signaling pathways, highlighting its role in intricate molecular networks.

SB 452533

459429-39-1sc-361346
sc-361346A
10 mg
50 mg
$135.00
$595.00
(0)

SB 452533 is a notable VR1 receptor modulator distinguished by its behavior as an acid halide. Its high reactivity enables efficient acylation reactions, leading to the formation of stable covalent bonds with nucleophilic sites. The compound's unique steric configuration and electronic distribution enhance its selectivity, allowing for precise interactions with biomolecular targets. This specificity can influence downstream signaling cascades, underscoring its role in complex biochemical processes.