Vmn2r62 Activators
Chemical activators of Vmn2r62 can initiate a cascade of intracellular events leading to the receptor's activation through various mechanisms. Sodium fluoride, for instance, activates G-protein coupled receptors (GPCRs) by promoting the exchange of GTP for GDP on the G-protein, which in turn activates downstream signaling. Similarly, aluminum chloride can induce phosphorylation events, altering the conformation of Vmn2r62 or activating signaling cascades that result in its activation. Cholesterol, while primarily involved in maintaining cell membrane integrity and fluidity, can also modulate the environment of Vmn2r62, facilitating its activation by promoting necessary conformational changes. Forskolin exerts a direct effect on adenylyl cyclase, escalating cAMP levels within the cell, which then activates protein kinase A (PKA). PKA can phosphorylate and activate GPCRs, including Vmn2r62.
Ionomycin raises intracellular calcium concentrations, subsequently activating kinases such as protein kinase C (PKC), which can phosphorylate Vmn2r62 leading to its activation. Kainic acid functions as a glutamate receptor agonist, and upon binding, it increases intracellular calcium, which might activate Vmn2r62 through similar phosphorylation pathways. Histamine, after binding to its specific GPCRs, can activate pathways that phosphorylate and activate Vmn2r62. Capsaicin targets the TRPV1 receptor, resulting in increased intracellular calcium that can activate Vmn2r62. Isoproterenol, a beta-adrenergic agonist, increases cAMP levels via Gs proteins, leading to PKA activation that can phosphorylate Vmn2r62. Glutamate, the principal excitatory neurotransmitter, upon engaging its receptors, activates downstream pathways that can culminate in the phosphorylation and activation of Vmn2r62. Lastly, acetylcholine and adenosine, by binding to their respective receptors, can also activate signaling pathways that lead to the activation of Vmn2r62 via increased cAMP and subsequent PKA-mediated phosphorylation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride is known to activate G-protein coupled receptors (GPCRs), leading to the activation of downstream signaling molecules. Vmn2r62, being a GPCR, can be activated through this pathway as sodium fluoride promotes the exchange of GTP for GDP on the G-protein, leading to activation. | ||||||
Aluminum chloride anhydrous | 7446-70-0 | sc-214528 sc-214528B sc-214528A | 250 g 500 g 1 kg | $92.00 $97.00 $133.00 | ||
Aluminum chloride can activate enzymatic activity that results in phosphorylation events within cells. These phosphorylation events can lead to the activation of Vmn2r62 by altering the receptor's conformation or by activating signaling cascades that directly lead to the receptor's activation. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Cholesterol is integral to the structure and function of cell membranes, where Vmn2r62 is located. It can modulate membrane fluidity and potentially lead to the activation of Vmn2r62 by changing the receptor's environment, facilitating its conformational change for activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, which increases the levels of cAMP in cells. Elevated cAMP can activate protein kinase A (PKA), which can phosphorylate and thereby activate GPCRs like Vmn2r62. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin functions as an ionophore for calcium, increasing intracellular calcium concentrations. The rise in calcium can activate kinases like PKC, which can then phosphorylate and activate GPCRs, including Vmn2r62. | ||||||
Kainic acid | 487-79-6 | sc-200454 sc-200454A sc-200454B sc-200454C sc-200454D | 5 mg 25 mg 100 mg 1 g 5 g | $85.00 $370.00 $1350.00 $7650.00 $24480.00 | 12 | |
Kainic acid is an agonist for glutamate receptors which, upon activation, can lead to increased intracellular calcium levels. This could activate signaling pathways that phosphorylate and activate Vmn2r62. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can bind to and activate its GPCRs, which can share signaling pathways with Vmn2r62. Activation of these pathways can lead to the phosphorylation and activation of Vmn2r62. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates the TRPV1 receptor, which can lead to increased intracellular calcium levels. This increase can activate signaling pathways that lead to the phosphorylation and activation of GPCRs such as Vmn2r62. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can activate adenylyl cyclase via Gs proteins, increasing cAMP levels, which in turn activate PKA. PKA phosphorylation can lead to activation of GPCRs like Vmn2r62. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
Glutamate is the primary excitatory neurotransmitter in the brain that binds to and activates glutamate receptors, which may share downstream signaling pathways with Vmn2r62, leading to the receptor's phosphorylation and activation. | ||||||