Vmn2r112 Activators
Chemical activators of Vmn2r112 engage in a cascade of intracellular events that culminate in the activation of this protein. Forskolin, which is known for its direct stimulation of adenylyl cyclase, results in an upsurge of cyclic AMP (cAMP) levels within the cell. This elevation in cAMP is a crucial step, as it leads to the activation of protein kinase A (PKA). PKA then proceeds to phosphorylate Vmn2r112, which is an essential modification for the activation of the protein. Similarly, Isoproterenol, a beta-adrenergic agonist, binds to beta-adrenoceptors and catalyzes the production of cAMP. This increase in cAMP mimics the action of forskolin by activating PKA, which in turn phosphorylates Vmn2r112. Epinephrine and norepinephrine also bind to beta-adrenergic receptors, initiating the same cascade resulting in Vmn2r112 activation through phosphorylation by PKA.
A diverse set of molecules influences the activity of Vmn2r112 through various pathways that converge on the production of cAMP and subsequent activation of PKA. Histamine, upon binding to H2 receptors, dopamine through D1-like receptors, and glucagon via its specific receptor, all stimulate adenylyl cyclase, which leads to increased levels of cAMP and PKA activation, ultimately resulting in the phosphorylation of Vmn2r112. Phosphodiesterase inhibitors like IBMX, cilostamide, rolipram, and anagrelide elevate cAMP levels by preventing its breakdown, thereby ensuring PKA activation and subsequent phosphorylation of Vmn2r112. Prostaglandin E1 (PGE1), also known as Alprostadil, additionally binds to its receptors and causes a rise in cAMP, leading to the activation of PKA and phosphorylation of Vmn2r112. Collectively, these chemical activators employ the cAMP-PKA signaling axis to modulate the activity of Vmn2r112 through phosphorylation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a synthetic catecholamine and beta-adrenergic agonist, binds to beta-adrenoceptors, stimulating cAMP production via adenylyl cyclase activation. Increased cAMP levels lead to PKA activation, which can phosphorylate and activate Vmn2r112. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine interacts with beta-adrenergic receptors, causing a rise in intracellular cAMP levels which activates PKA. PKA can then phosphorylate and lead to the activation of Vmn2r112. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine binds to beta-adrenergic receptors, similarly leading to an increase in intracellular cAMP and activation of PKA, which may then phosphorylate and activate Vmn2r112. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, upon interaction with H2 receptors, results in an increased production of cAMP. The subsequent activation of PKA can lead to the phosphorylation and activation of Vmn2r112. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to its receptors, particularly D1-like receptors that stimulate adenylyl cyclase, increasing cAMP levels. This increase can activate PKA, which in turn can activate Vmn2r112 through phosphorylation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX acts as a nonspecific inhibitor of phosphodiesterases, preventing cAMP degradation. Higher levels of cAMP result in PKA activation, which can then phosphorylate and activate Vmn2r112. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $92.00 $357.00 | 16 | |
Cilostamide selectively inhibits phosphodiesterase 3 (PDE3), leading to an increase in cAMP levels. Elevated cAMP activates PKA, which can then phosphorylate and activate Vmn2r112. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram, a selective phosphodiesterase 4 inhibitor, increases intracellular cAMP levels, which activates PKA. Activated PKA can phosphorylate and activate Vmn2r112. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
PGE1, also known as Alprostadil, binds to prostaglandin receptors, leading to increased cAMP levels. The activation of PKA by cAMP may lead to the phosphorylation and activation of Vmn2r112. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $150.00 | ||
Anagrelide inhibits phosphodiesterase 3, resulting in increased cAMP levels. The cAMP activates PKA, which can phosphorylate and activate Vmn2r112. | ||||||