Vmn1r151 Inhibitors
Vmn1r151, a key member of the vomeronasal 1 receptor family, holds a central role in the intricate world of sensory perception, particularly in the detection of pheromones. Positioned within the vomeronasal organ, this receptor contributes to the decoding of chemical cues, shaping essential aspects of social behaviors in response to environmental stimuli. Vmn1r151 is intricately linked to several signaling pathways, notably the PI3K/Akt, MAPK/ERK, and JNK cascades, through which it transduces signals from pheromones, orchestrating nuanced cellular responses within the sensory neurons.
In terms of inhibition, the regulatory mechanisms of Vmn1r151 unfold through a complex interplay of diverse signaling pathways. The inhibitors outlined in the table exert their effects by disrupting critical nodes within these cascades. For instance, PI3K/Akt pathway inhibitors interfere with downstream signaling events associated with Vmn1r151, causing alterations in its expression and function. Similarly, inhibition of the MAPK/ERK and JNK cascades disrupts the intricate signaling dynamics orchestrated by Vmn1r151, leading to modifications in its activity. The underlying mechanisms of inhibition involve the perturbation of these pathways, influencing phosphorylation dynamics, protein-protein interactions, and downstream cellular responses associated with Vmn1r151. As a result, the receptor's role in decoding pheromone signals is intricately regulated by the modulation of these signaling pathways, providing valuable insights into the complex interplay between molecular events and sensory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3-kinase inhibitor, disrupting the PI3K/Akt pathway. Vmn1r151 is intricately connected to this pathway, and Wortmannin indirectly inhibits Vmn1r151 by perturbing downstream signaling events, leading to alterations in Vmn1r151 expression and function within the cellular context. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a selective PI3-kinase inhibitor, perturbing the PI3K/Akt pathway. Vmn1r151 is associated with this pathway, and LY294002 indirectly inhibits Vmn1r151 by influencing downstream signaling cascades, causing modifications in Vmn1r151 expression and function within the cellular milieu. | ||||||
PD 169316 | 152121-53-4 | sc-204168 sc-204168A sc-204168B sc-204168C | 1 mg 5 mg 10 mg 25 mg | $88.00 $156.00 $281.00 $461.00 | 3 | |
SB203580 is a p38 MAPK inhibitor, perturbing MAPK signaling. Vmn1r151, being downstream in this pathway, is indirectly influenced by SB203580. The inhibition occurs through perturbation of p38 MAPK signaling, leading to modifications in Vmn1r151 expression and function within the cellular context. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor, disrupting the MAPK pathway. Vmn1r151 is positioned downstream in this pathway, and its activity is indirectly influenced by PD98059. The inhibition occurs through perturbation of the MAPK signaling cascade, leading to modifications in Vmn1r151 expression and function within the cellular milieu. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, affecting the JNK signaling pathway. Vmn1r151 is indirectly influenced by SP600125, positioned downstream in the JNK pathway. The inhibition occurs through perturbation of the JNK cascade, leading to modifications in Vmn1r151 expression and function within the cellular context. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent protein phosphatase inhibitor, disrupting cellular phosphorylation dynamics. Vmn1r151 activity is modulated by phosphorylation events, and Calyculin A indirectly inhibits Vmn1r151 by influencing protein phosphatase activity, resulting in altered phosphorylation patterns that impact Vmn1r151 function within the cell. | ||||||