The chemical class denoted as VCX-B Inhibitors represents a collection of compounds strategically designed to selectively target VCX-B, a molecular entity associated with reproductive biology and male fertility. VCX-B, or Variable Charge X-linked protein-B, is a member of the VCX gene family located on the X chromosome. The specific functions and regulatory mechanisms of VCX-B are areas of active exploration within the field of reproductive genetics. While the broader VCX family is recognized for its involvement in spermatogenesis and male reproductive health, the unique characteristics of VCX-B and its precise role in cellular processes remain subjects of investigation for researchers. Inhibitors within the VCX-B Inhibitors class are intricately engineered molecules with the primary goal of modulating the activity or function of VCX-B, thereby inducing an inhibitory effect. Researchers in this field adopt a multidisciplinary approach, combining insights from molecular genetics, structural biology, and medicinal chemistry to understand the complex molecular interactions between the inhibitors and the target VCX-B.
Structurally, VCX-B Inhibitors are characterized by specific molecular features tailored to facilitate selective binding to VCX-B. This selectivity is crucial to minimize unintended effects on other VCX family members or cellular components, ensuring a focused impact on the intended molecular target. The development of inhibitors within this chemical class involves a thorough exploration of structure-activity relationships, optimization of pharmacokinetic properties, and a deep understanding of the molecular mechanisms associated with VCX-B. As researchers delve deeper into the functional aspects of VCX-B Inhibitors, the knowledge generated contributes not only to deciphering the specific roles of Variable Charge X-linked protein-B but also to advancing our broader comprehension of male reproductive biology and the intricate molecular events governing fertility processes. The exploration of VCX-B Inhibitors stands as a significant avenue for expanding fundamental knowledge in reproductive genetics and cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
It intercalates into DNA, preventing RNA synthesis by RNA polymerase, which can lead to a decrease in protein expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
It inhibits eukaryotic protein synthesis by interfering with the translocation step in the ribosome. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
It binds to FKBP12 and inhibits mTOR, a key regulator of protein synthesis. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
It exhibits multiple mechanisms, including inhibition of transcription factors and RNA polymerase II. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
It inhibits RNA polymerase II transcriptional elongation. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
It is a potent inhibitor of RNA polymerase II in eukaryotes, leading to decreased mRNA production. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
It is an inhibitor of histone deacetylases (HDACs), which can result in altered chromatin structure and reduced gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
It is incorporated into DNA and RNA, leading to hypomethylation of DNA and potentially affecting gene expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
It can intercalate into DNA and RNA, which can inhibit DNA replication and RNA synthesis. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
It inhibits topoisomerase I, leading to DNA damage and potential inhibition of transcription. | ||||||