UTP6 Inhibitors

UTP6 inhibitors LY294002 and Wortmannin are both inhibitors of the PI3K family, which play a pivotal role in transducing signals from growth factors and other extracellular stimuli to intracellular responses, including those related to protein synthesis and turnover. PD98059, U0126, and SB203580 belong to the class of MAPK pathway inhibitors, which are crucial in regulating cellular responses to a variety of stimuli, impacting protein expression and activity.

Rapamycin is an inhibitor of the mTOR pathway, which is central to cell growth and metabolism. Inhibition of mTOR can influence numerous proteins that facilitate cell cycle progression and growth. PP2 and Genistein impact protein function by inhibiting tyrosine kinases, which are important for the activation of many types of cellular proteins. The JNK pathway, targeted by SP600125, is involved in stress response and apoptosis, thereby influencing protein function related to these processes. NF449 and Brefeldin A disrupt G-protein signaling and protein trafficking, respectively, pointing to a broad impact on protein function and signaling. Finally, Y-27632 inhibits ROCK, which is involved in regulating cell shape, motility, and contraction, all of which can impact the function of proteins related to these cellular events.