UT-B Activators
UT-B activators encompass a diverse range of chemicals that indirectly modulate UT-B activity, primarily through the manipulation of intracellular cAMP levels and the activation of protein kinase A (PKA). This group includes both endogenous activators and exogenous activators. The primary mechanism of action in this class is the elevation of cAMP, either through direct stimulation of adenylyl cyclase or through inhibition of phosphodiesterases, which degrade cAMP. This increase in cAMP levels leads to the activation of PKA. PKA then potentially modulates the activity of UT-B either through direct phosphorylation or by altering its cellular localization or expression levels.
Moreover, this class includes activatos which exert their effects through specific G protein-coupled receptor pathways, and histamine, which acts through the H2 receptor. The complexity and diversity of these activators reflect the intricate network of signaling pathways that converge on the modulation of UT-B.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can activate PKA, which may influence UT-B activity by phosphorylation or altering cellular localization. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX acts as a non-selective inhibitor of phosphodiesterases, preventing cAMP degradation. This elevation in cAMP levels can indirectly enhance PKA activity, potentially affecting UT-B. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to adrenergic receptors, leading to increased cAMP production via G protein-coupled receptor signaling. This, in turn, activates PKA, which may modulate UT-B. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, increases cAMP production by stimulating adenylyl cyclase. The resultant PKA activation can indirectly influence UT-B. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, leading to an accumulation of cAMP and subsequent activation of PKA, which may indirectly affect UT-B functioning. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) binds to EP receptors, activating adenylyl cyclase and increasing cAMP levels, which may result in PKA-mediated modulation of UT-B. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to increased cAMP levels and potentially enhancing PKA activity, which could influence UT-B. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Similar to caffeine, theophylline inhibits phosphodiesterases, elevating cAMP and indirectly activating PKA, potentially affecting UT-B activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, through specific GPCRs, can increase cAMP levels in certain cell types, leading to PKA activation which might modulate UT-B. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine, by binding to its receptors, can either increase or decrease cAMP depending on the receptor subtype, potentially influencing PKA and UT-B. | ||||||