Twinfilin-1 Inhibitors
Twinfilin-1 inhibitors are chemical compounds that target and inhibit Twinfilin-1, a protein known for its role in actin cytoskeleton dynamics. Twinfilin-1 is an actin-binding protein that regulates the polymerization and depolymerization of actin filaments, essential processes for cell motility, shape, and division. By binding to actin monomers and filaments, Twinfilin-1 modulates the organization and dynamics of the actin cytoskeleton. The inhibitors of Twinfilin-1 interfere with these interactions, thereby affecting the actin cytoskeleton's structure and function. These inhibitors typically feature a combination of functional groups and structural motifs that mimic the natural binding partners of Twinfilin-1 or competitively inhibit its binding sites.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits eukaryotic protein synthesis, potentially reducing Twinfilin-1 levels by preventing its translation. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Interacts with DNA and inhibits RNA polymerase, which could decrease Twinfilin-1 mRNA synthesis and thus its protein levels. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Inhibits transcription by RNA polymerase II, potentially downregulating Twinfilin-1 expression. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Forms DNA crosslinks, potentially preventing transcription of genes including that which encodes Twinfilin-1. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits DNA topoisomerase I, leading to reduced transcription and potential downregulation of Twinfilin-1 expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Specifically inhibits RNA polymerase II, potentially decreasing Twinfilin-1 synthesis. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibits RNA polymerase II transcription, possibly reducing Twinfilin-1 expression. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Inhibits cyclin-dependent kinases, which can lead to reduced transcription and potentially lower levels of Twinfilin-1. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $186.00 $674.00 | 10 | |
Disrupts hypoxia-inducible transcription factor activity, which could indirectly lower Twinfilin-1 expression. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Inhibits translation initiation and could therefore decrease Twinfilin-1 protein production. | ||||||