Tubulin Inhibitors
Items 21 to 30 of 31 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
XRP44X | 729605-21-4 | sc-204404 sc-204404A | 10 mg 50 mg | $175.00 $739.00 | ||
XRP44X acts as a potent disruptor of tubulin dynamics by selectively binding to the colchicine site on tubulin dimers. This interaction stabilizes the tubulin conformation, hindering the assembly of microtubules and promoting depolymerization. The compound's unique ability to modulate GTPase activity alters the kinetics of tubulin assembly, leading to a significant reduction in microtubule stability and affecting cellular motility and organization. | ||||||
Tubulin Polymerization Inhibitor II | 1151995-69-5 | sc-296673 | 5 mg | $140.00 | ||
Tubulin Polymerization Inhibitor II functions by targeting the interface between tubulin subunits, disrupting the normal polymerization process. Its binding alters the conformational flexibility of tubulin, preventing the formation of stable microtubule structures. This compound also influences the dynamics of GTP binding and hydrolysis, resulting in a shift in the equilibrium between polymerized and unpolymerized tubulin, ultimately destabilizing the microtubule network within cells. | ||||||
Colchicine-d3 | sc-217947 | 1 mg | $360.00 | |||
Colchicine-d3 acts as a potent disruptor of microtubule dynamics by binding to the colchicine site on tubulin. This interaction inhibits the assembly of tubulin dimers into microtubules, leading to a reduction in polymerization rates. The compound's unique isotopic labeling allows for precise tracking in biochemical assays, enhancing the understanding of tubulin dynamics and the effects of microtubule-targeting agents on cellular processes. Its influence on GTPase activity further modulates the stability of the cytoskeletal framework. | ||||||
ABT 751 | 141430-65-1 | sc-361097 sc-361097A | 10 mg 50 mg | $179.00 $825.00 | ||
ABT 751 is a selective inhibitor of tubulin polymerization, exhibiting a unique mechanism of action by binding to the colchicine site on β-tubulin. This interaction disrupts the normal assembly of microtubules, leading to a decrease in their stability. The compound also modulates the dynamics of GTP binding and hydrolysis, influencing the overall kinetics of microtubule turnover. Its distinct ability to interfere with tubulin's structural integrity highlights its role in cellular processes. | ||||||
Indibulin | 204205-90-3 | sc-295179 sc-295179A | 10 mg 50 mg | $145.00 $829.00 | ||
Indibulin is a selective inhibitor of tubulin polymerization, engaging with the β-tubulin subunit to disrupt microtubule formation. This compound alters the dynamics of microtubule assembly by stabilizing a conformation that prevents the incorporation of tubulin dimers. Its unique binding affinity influences the kinetics of microtubule turnover, leading to altered cellular architecture. Additionally, Indibulin's interactions can modulate intracellular transport mechanisms, impacting various cellular functions. | ||||||
Phomopsin A | 64925-80-0 | sc-202282 sc-202282A sc-202282B | 1 mg 5 mg 10 mg | $480.00 $1300.00 $2200.00 | 1 | |
Phomopsin A is a potent disruptor of tubulin dynamics, specifically targeting the α- and β-tubulin heterodimer. It binds with high specificity, inducing conformational changes that hinder microtubule assembly and stability. This compound uniquely alters the GTPase activity of tubulin, affecting the rate of polymerization and depolymerization. Its influence on microtubule dynamics can lead to significant alterations in cellular motility and structural integrity, showcasing its distinct biochemical behavior. | ||||||
PX 12 | 141400-58-0 | sc-358518 sc-358518A | 10 mg 50 mg | $130.00 $495.00 | 9 | |
PX 12 acts as a potent disruptor of tubulin dynamics, specifically targeting the α/β-tubulin interface. By stabilizing the tubulin dimer, it alters the equilibrium between polymerized and unpolymerized states, effectively hindering microtubule assembly. This compound also influences the GTPase activity of tubulin, impacting the rate of microtubule depolymerization. Its unique interactions with the tubulin structure provide insights into cellular motility and division processes. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $209.00 | 1 | |
Albendazole exhibits a distinctive mechanism of action by binding to the β-tubulin subunit, leading to the inhibition of microtubule polymerization. This interaction disrupts the dynamic instability of microtubules, favoring their disassembly. Additionally, it alters the conformational state of tubulin, affecting the assembly kinetics and stability of the microtubule network. Such alterations can significantly impact cellular processes reliant on microtubule integrity and function. | ||||||
iso-Colchicine-d3 | 1246818-69-8 | sc-218605 | 5 mg | $330.00 | ||
Iso-Colchicine-d3 exhibits a selective affinity for tubulin, engaging in specific interactions that disrupt microtubule integrity. This compound alters the equilibrium between polymerized and unpolymerized tubulin, favoring depolymerization. Its unique isotopic labeling allows for precise tracking in biochemical assays, providing insights into tubulin dynamics. Additionally, iso-Colchicine-d3 influences the kinetics of microtubule assembly, impacting cellular architecture and motility. | ||||||
N-(2-Mercaptoethyl) Demecolcine | 1217746-74-1 | sc-218920 | 10 mg | $380.00 | ||
N-(2-Mercaptoethyl) Demecolcine interacts with tubulin through unique thiol groups, facilitating the formation of disulfide bonds that destabilize microtubule structures. This compound modulates the dynamics of tubulin polymerization by preferentially binding to specific sites, leading to altered assembly rates. Its distinct reactivity enhances the understanding of microtubule behavior in cellular processes, offering insights into the mechanistic pathways of cytoskeletal regulation. | ||||||