Tub Activators
Tub activators represent a specific category of chemical agents developed to enhance or mimic the activation of the protein Tub, a signaling molecule that is part of the TUBBY family of proteins. Tub, the protein encoded by the TUB gene, is involved in the regulation of various cellular processes, including signal transduction, gene expression, and the maintenance of metabolic balance. It plays a role in the proper functioning of neurons and is thought to be involved in the transport of certain molecules to and from the cell nucleus.
The activation of Tub by these compounds can occur via direct or indirect means. Direct Tub activators may bind to the Tub protein and induce a conformational shift that either enhances its natural activity or initiates a specific active state. This could include increasing its binding affinity to other proteins or substrates in signal transduction pathways, thereby amplifying the protein's signaling capacity. By directly stimulating the activity of Tub, these activators could effectively boost the cellular processes that Tub regulates. Indirect Tub activators can affect the protein's activity by modulating the cellular environment or impacting other molecular pathways that influence Tub function. This might involve the regulation of upstream signaling molecules that lead to the activation of Tub, or it could be through the alteration of cellular factors that control the expression levels of the Tub gene, resulting in increased synthesis of the Tub protein. Additionally, such activators might promote post-translational modifications of Tub that are necessary for its activation or enhance its interaction with other proteins that facilitate its proper functioning.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP can modulate various signaling pathways, potentially influencing Tub by altering cellular signaling dynamics, particularly in pathways where Tub is a downstream effector. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, affecting cell growth and metabolism. By inhibiting mTOR signaling, rapamycin can indirectly influence Tub through alterations in cellular growth and energy signaling pathways, which may intersect with Tub's functions. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
An AMPK activator, influencing cellular energy metabolism. Metformin's activation of AMPK can modulate mitochondrial function and biogenesis, potentially affecting Tub expression or activity in the context of energy metabolism regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates SIRT1, influencing cellular stress responses and mitochondrial function. SIRT1 activation can lead to modulation of pathways that may intersect with Tub's function, potentially affecting its expression or activity in response to altered mitochondrial dynamics and stress signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Known to modulate multiple signaling pathways, including those related to cellular stress and metabolism. Curcumin's effects could indirectly influence Tub by altering cellular signaling dynamics and stress responses. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
A glycolysis inhibitor, inducing cellular energy stress. By altering cellular energy metabolism, 2-Deoxy-D-glucose can influence Tub expression or activity as part of the cellular adaptation to energy stress. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor, which can alter cellular response to stress or inflammation. By modulating p38 MAPK, SB203580 could indirectly affect Tub's function or expression by changing the cellular signaling milieu. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, impacting the AKT signaling pathway. The modulation of this pathway can influence Tub indirectly by altering cellular survival, proliferation, and metabolism signals. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, part of the MAPK signaling pathways. By inhibiting JNK, SP600125 could indirectly influence Tub's function or expression by altering stress and inflammatory response signals. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor, impacting cell shape and motility. This could affect Tub by altering cellular architecture and signaling related to cytoskeletal dynamics. | ||||||