TTC17 Inhibitors

TTC17 inhibitors are chemicals that can modulate cellular pathways in which TTC17 or related proteins operate. Tetratricopeptide repeat (TPR) motifs are sequence-specific modules involved in protein-protein interactions. A number of the listed chemicals, such as Rapamycin, Cyclosporine, and FK506, exert their biological effects by interacting with proteins that contain TPR motifs. Their impact on signaling pathways underscores the intricate networks in which TPR-containing proteins like TTC17 might be involved.

HSP90 inhibitors, including Geldanamycin, 17-AAG, and Radicicol, target a heat shock protein whose co-chaperones often contain TPR motifs. Given this association, it's plausible that these inhibitors could indirectly influence TTC17 function or stability. The list also includes agents affecting cell proliferation, DNA/RNA synthesis, and protein degradation like Methotrexate, 5-Fluorouracil, Roscovitine, MG132, and Bortezomib. All these agents illustrate the broad cellular landscape and the crosstalk between TPR-containing proteins and various cellular pathways.