TTC12 Activators
TTC12 Activators are a series of chemical compounds that facilitate the enhancement of TTC12's functional role within various cellular signaling networks. Compounds such as Forskolin and IBMX operate by elevating intracellular cAMP levels, thereby potentially augmenting TTC12 function through the activation of cAMP-dependent protein kinase (PKA) pathways that TTC12 could be associated with. Phorbol 12-myristate 13-acetate (PMA), through its activation of protein kinase C (PKC), might indirectly boost TTC12 activity by influencing PKC-mediated signaling cascades. Similarly, Sphingosine-1-phosphate (S1P) engages G protein-coupled receptors to initiate cellular responses that could enhance TTC12 activity, while calcium ionophores like Ionomycin and A23187 can elevate intracellular calcium, which may indirectly promote TTC12's role in calcium-dependent signaling pathways.
Furthermore, the kinase inhibitor Epigallocatechin gallate (EGCG) and the PI3K inhibitor LY294002 could indirectly facilitate the enhancement of TTC12 by modulating respective kinase and PI3K/AKT signaling pathways. U0126, as a MEK inhibitor, might support the functional activity of TTC12 by altering MEK/ERK signaling. Rolipram, by inhibiting PDE4, and Anisomycin, through its activation of stress-activated protein kinases, contribute to the activation of cAMP-dependent and stress response pathways, respectively, which could indirectly lead to the enhancement of TTC12 activity. SB203580, by inhibiting p38 MAPK, may also shift signaling dynamics to favor TTC12
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which in turn could enhance TTC12 activity by promoting cAMP-dependent protein kinase (PKA) signaling pathways that TTC12 may interact with. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, enzymes that break down cAMP. Elevated cAMP levels might enhance TTC12 activity through similar mechanisms as Forskolin. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which could indirectly enhance the activity of TTC12 by modulating PKC-dependent signaling pathways where TTC12 is involved. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P activates G protein-coupled receptors, which may lead to downstream effects on signaling pathways that enhance TTC12 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially affecting calcium-dependent signaling pathways and indirectly enhancing TTC12 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that may indirectly enhance TTC12 activity by modulating kinase-dependent signaling pathways where TTC12 participates. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that may enhance TTC12 activity by altering PI3K-dependent signaling pathways in which TTC12 is involved. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that could indirectly enhance TTC12 activity by modulating the MEK/ERK pathway and its downstream signaling processes. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), leading to an increase in cAMP levels, which could enhance TTC12 activity through cAMP-dependent pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases, potentially enhancing TTC12 activity via stress response pathways. | ||||||