TRPV5 Inhibitors
TRPV5 inhibitors belong to a specific chemical class of compounds that are known for their ability to modulate the activity of the Transient Receptor Potential Vanilloid 5 (TRPV5) ion channel. TRPV5 is a member of the TRP superfamily of ion channels, which are involved in regulating calcium ion transport across cell membranes. These inhibitors work by specifically targeting and binding to TRPV5, leading to a decrease in its channel activity. As a consequence, the influx of calcium ions through TRPV5 channels is hindered, affecting calcium homeostasis in various tissues and cells. The mechanism of action of TRPV5 inhibitors involves their interaction with specific binding sites on the TRPV5 protein, resulting in conformational changes that impede the passage of calcium ions. By inhibiting TRPV5, these compounds play a crucial role in the regulation of calcium ion concentrations, which is vital for various cellular processes such as muscle contraction, neurotransmitter release, and bone mineralization. Their selectivity for TRPV5 channels differentiates them from other classes of calcium channel inhibitors, making them potentially valuable tools for research in cellular calcium signaling and related physiological functions.
Scientists and researchers utilize TRPV5 inhibitors to investigate the biological functions of TRPV5 in both normal and pathological conditions. By perturbing the calcium flux through these channels, researchers can gain insights into the channel's role in various cellular processes, which may have implications for understanding diseases linked to abnormal calcium regulation. Overall, TRPV5 inhibitors represent a valuable class of compounds in the field of calcium channel modulation research, providing a specific and targeted means to investigate TRPV5's function and its potential relevance in various physiological and pathophysiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Acts as a broad-spectrum inhibitor of TRP channels, including TRPV5, by interfering with channel gating mechanisms, thereby hindering calcium influx through TRPV5. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Functions as a TRPV5 inhibitor by binding to the channel, altering its conformation, and reducing its permeability to calcium ions, independent of its antifungal properties. | ||||||
2,5-Dimethyl Celecoxib | 457639-26-8 | sc-497898 | 25 mg | $300.00 | ||
A celecoxib derivative, not acting through COX-2 inhibition but directly inhibiting TRPV5 channels by altering channel gating and reducing calcium conductance. | ||||||
3′,4′-Dihydroxyflavone | 4143-64-0 | sc-267003 | 100 mg | $111.00 | ||
This flavonoid inhibits TRPV5 activity by binding to the extracellular domain of the channel, leading to a decrease in calcium permeability. | ||||||
Tolfenamic Acid | 13710-19-5 | sc-204918 sc-204918A | 5 g 25 g | $69.00 $312.00 | ||
Exerts its inhibitory effects on TRPV5 by binding to and altering the channel structure, which decreases its ability to conduct calcium ions. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
Initially identified as a calmodulin inhibitor, it also inhibits TRPV5 channels by blocking the channel pore or altering its gating mechanism, reducing calcium entry. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Inhibits TRPV5 function by directly interacting with the channel, potentially altering its conformation and decreasing calcium conductance, unrelated to its use in asthma management. | ||||||