Topo II Inhibitors
Items 61 to 64 of 64 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bis(cyclopentadienyl)vanadium(IV) dichloride | 12083-48-6 | sc-227388 | 1 g | $58.00 | ||
Bis(cyclopentadienyl)vanadium(IV) dichloride exhibits unique interactions with topoisomerase II through its metal-centered coordination, which influences the enzyme's conformational dynamics. The compound's distinct ligand environment facilitates specific binding to the enzyme, altering its catalytic pathways. This results in a modulation of DNA supercoiling and strand passage, as the vanadium center introduces unique electronic properties that affect reaction kinetics and enzyme stability, ultimately impacting DNA topology. | ||||||
Protocatechuic acid ethyl ester | 3943-89-3 | sc-236496 | 5 g | $32.00 | ||
Protocatechuic acid ethyl ester engages with topoisomerase II through its aromatic structure, which enhances π-π stacking interactions with the enzyme's active site. This compound's ethyl ester moiety contributes to hydrophobic interactions, promoting a favorable binding affinity. The presence of hydroxyl groups allows for hydrogen bonding, influencing the enzyme's conformational state and catalytic efficiency, thereby modulating DNA relaxation and torsional strain during replication processes. | ||||||
Sobuzoxane | 98631-95-9 | sc-215862 sc-215862A sc-215862B sc-215862C | 5 mg 25 mg 50 mg 100 mg | $255.00 $918.00 $1530.00 $2856.00 | 1 | |
Sobuzoxane exhibits unique interactions with topoisomerase II, primarily through its ability to form stable complexes via electrostatic and hydrophobic interactions. Its structural features facilitate the disruption of the enzyme's catalytic cycle, leading to the stabilization of DNA cleavage complexes. The compound's specific conformational flexibility allows it to adapt to the enzyme's active site, influencing reaction kinetics and altering the dynamics of DNA topology during replication and repair processes. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $265.00 | 9 | |
Fostriecin interacts with topoisomerase II by forming transient complexes that modulate the enzyme's activity. Its unique binding affinity stems from specific hydrogen bonding and van der Waals interactions, which enhance the stabilization of the enzyme-DNA complex. This compound also exhibits a distinctive ability to alter the conformational state of topoisomerase II, impacting the enzyme's catalytic efficiency and influencing the resolution of DNA supercoiling during cellular processes. | ||||||