TNF-IP 8 Activators
Chemical activators of TNF-IP 8 can initiate a cascade of intracellular signaling pathways leading to its functional activation. PMA, a potent activator of protein kinase C (PKC), instigates a series of events that culminate in the activation of the NF-κB pathway. This is a central mechanism by which TNF-IP 8 is activated, as NF-κB is a pivotal transcription factor that regulates the expression of various immune response genes. Similarly, Thapsigargin, by disrupting calcium homeostasis through inhibition of the SERCA pump, can raise cytosolic calcium levels, which in turn can activate NF-κB. Ionomycin also raises intracellular calcium concentrations, which activates calcium-dependent proteins that can engage NF-κB signaling. Activation of this pathway influences the functional state of TNF-IP 8.
Other stress-inducing agents, such as Tunicamycin and Brefeldin A, induce endoplasmic reticulum (ER) stress and activate the unfolded protein response (UPR), a cellular stress response related to the ER. Activation of the UPR can lead to NF-κB activation, which then promotes the functional activation of TNF-IP 8. Anisomycin interferes with protein synthesis and activates stress-activated protein kinases, which can activate NF-κB and other signaling pathways, influencing TNF-IP 8 activity. Furthermore, compounds such as Sulforaphane, Betulinic Acid, and Curcumin, which affect oxidative stress responses and other signaling molecules, can modulate NF-κB signaling. Capsaicin, through the activation of VR1, causes an influx of calcium ions that can stimulate NF-κB signaling. Lastly, Resveratrol and Arsenic Trioxide can alter the functional state of TNF-IP 8 through modulation of NF-κB signaling, the former via activation of SIRT1 and AMPK, and the latter through induction of oxidative stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in signaling pathways that lead to activation of NF-κB. TNF-IP 8 is known to be regulated by NF-κB, thus PMA's activation of PKC subsequently leads to the activation of NF-κB, promoting the functional activation of TNF-IP 8. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin induces endoplasmic reticulum stress by inhibiting the SERCA pump, which causes an increase in cytosolic calcium levels that can activate calcium-dependent signaling pathways, including NF-κB. Activation of NF-κB can lead to the functional activation of TNF-IP 8. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which can activate calcium-dependent proteins and pathways, including NF-κB. The activation of NF-κB signaling is a pathway that leads to the functional activation of TNF-IP 8. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin triggers endoplasmic reticulum stress by inhibiting N-linked glycosylation, leading to the activation of the unfolded protein response (UPR). The UPR activates NF-κB, a transcription factor that can upregulate the functional activity of TNF-IP 8. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus and endoplasmic reticulum function, inducing ER stress and the UPR, which is known to activate NF-κB signaling. The activation of NF-κB signaling can lead to the functional activation of TNF-IP 8. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin acts as a protein synthesis inhibitor that also activates stress-activated protein kinases, leading to the activation of JNK, p38 MAPK, and NF-κB pathways. The activation of these pathways can lead to the functional activation of TNF-IP 8. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which is involved in the cellular stress response. The Nrf2 pathway can interact with NF-κB signaling, which may lead to the functional activation of TNF-IP 8. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid induces oxidative stress and activates the NF-κB pathway. The activation of NF-κB signaling by oxidative stress can lead to the functional activation of TNF-IP 8. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate the NF-κB pathway by modulating the oxidative stress response and other signaling molecules involved in this pathway. Through the activation of NF-κB, curcumin can lead to the functional activation of TNF-IP 8. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates VR1 (transient receptor potential vanilloid 1) which leads to Ca2+ influx and subsequent activation of the NF-κB pathway. The activation of NF-κB can lead to the functional activation of TNF-IP 8. | ||||||