TNFα-IP 2 Activators
TNFα-Induced Protein 2 (TNFα-IP2), also known as TNFAIP2, is a protein encoded by the TNFAIP2 gene in humans. It belongs to the TNFα-induced protein (TNFAIP) family and is implicated in various cellular processes, particularly those related to inflammation and immune responses. One of the primary functions of TNFα-IP2 is its involvement in mediating cellular responses to tumor necrosis factor alpha (TNFα), a pro-inflammatory cytokine crucial for regulating immune responses and inflammation. Upon activation by TNFα, TNFα-IP2 is rapidly induced and serves as a downstream effector molecule, playing a pivotal role in transducing signals from the extracellular environment to the intracellular machinery.
The activation of TNFα-IP2 involves intricate signaling cascades initiated by the binding of TNFα to its cognate receptors on the cell surface. Upon ligand binding, TNFα receptors undergo conformational changes and recruit intracellular adaptor proteins, leading to the activation of downstream signaling pathways such as the NF-κB and MAPK pathways. These signaling cascades converge to induce the expression of TNFα-IP2 at the transcriptional level. Once synthesized, TNFα-IP2 modulates various cellular processes by interacting with specific target molecules or transcription factors, thereby regulating gene expression, cell survival, proliferation, and inflammation. The activation of TNFα-IP2 highlights its role as a key mediator in the cellular response to TNFα stimulation, contributing to the orchestration of inflammatory and immune responses in physiological and pathological conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation by blocking IκB phosphorylation and degradation. As TNFα-IP 2 is associated with NF-κB signaling, BAY 11-7082 indirectly activates TNFα-IP 2 by preventing its negative regulation through the NF-κB pathway. | ||||||
Amlexanox | 68302-57-8 | sc-217630 | 10 mg | $160.00 | 2 | |
Amlexanox inhibits IκB kinase ε (IKKε) and TANK-binding kinase 1 (TBK1), affecting the NF-κB pathway. By suppressing IKKε/TBK1 activity, Amlexanox indirectly activates TNFα-IP 2 through modulation of NF-κB signaling, relieving negative regulation on TNFα-IP 2. | ||||||
BAY 11-7085 | 196309-76-9 | sc-202490 sc-202490A | 10 mg 50 mg | $122.00 $516.00 | 55 | |
Similar to BAY 11-7082, Bay 11-7085 inhibits NF-κB activation, contributing to the indirect activation of TNFα-IP 2 by preventing its negative regulation through the NF-κB pathway. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium Salicylate inhibits NF-κB activation by preventing IκB degradation. This inhibition indirectly activates TNFα-IP 2 by modulating the NF-κB signaling pathway and preventing negative regulation on TNFα-IP 2. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $130.00 | 12 | |
Inhibition of IKK2 activity by TPCA-1 indirectly activates TNFα-IP 2 by preventing its negative regulation through the NF-κB signaling cascade. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Sanguinarium inhibits NF-κB activation by suppressing IκBα phosphorylation. Through NF-κB modulation, Sanguinarine indirectly activates TNFα-IP 2 by relieving negative regulation through the NF-κB signaling pathway. | ||||||
SC514 | 354812-17-2 | sc-205504 sc-205504A | 5 mg 10 mg | $66.00 $89.00 | 13 | |
SC-514 is a selective inhibitor of IKK2, impacting the NF-κB pathway. By inhibiting IKK2, SC-514 indirectly activates TNFα-IP 2 by preventing its negative regulation through the NF-κB signaling cascade. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide inhibits NF-κB activation by preventing IκB degradation. Through NF-κB modulation, Parthenolide indirectly activates TNFα-IP 2 by relieving negative regulation through the NF-κB signaling pathway. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol inhibits NF-κB activation by blocking IκB phosphorylation. The inhibition of NF-κB indirectly activates TNFα-IP 2 by preventing negative regulation through the NF-κB signaling pathway. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin inhibits NF-κB activation by suppressing IκBα phosphorylation. Through NF-κB modulation, Aspirin indirectly activates TNFα-IP 2 by relieving negative regulation through the NF-κB signaling pathway. | ||||||