Molecular structure of Celastrol, Celastrus scandens, CAS Number: 34157-83-0
Celastrol, Celastrus scandens (CAS 34157-83-0)
See product citations (6)
Alternate Names:
Tripterine
Application:
Celastrol, Celastrus scandens is an antiproliferative, antipreroxidative, and inhibits Topo II
CAS Number:
34157-83-0
Purity:
≥98%
Molecular Weight:
450.61
Molecular Formula:
C29H38O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Celastrol, Celastrus scandens, a compound originally purified from Tripterygium wilfordii, may act to be an anti-peroxidative and anti-angiogenic agent. Mechanistic studies suggest that Celastrol, Celastrus scandens suppresses levels of VEGF and Flk-1 receptors, VEGFR-1 and VEGFR-2, which may reduce signal transduction between the two growth factors. Additionally, Celastrol, Celastrus scandens has demonstrated the ability to disrupt critical interaction of Glu33 (Hsp90) and Arg167 (Cdc37) in the superchaperone complex which causes anti-proliferative activity in vitro and inhibit Topo II (topoisomerase II) activity in vitro (IC50 = 7.41 muM). Celastrol, Celastrus scandens is an inhibitor of Hsp90.
Celastrol, Celastrus scandens (CAS 34157-83-0) References
- Tripterine inhibits the expression of adhesion molecules in activated endothelial cells. | Zhang, DH., et al. 2006. J Leukoc Biol. 80: 309-19. PMID: 16769766
- [Tripterine inhibits all-trans retinoic acid-caused adhesion between leukemia cells and endothelial cells]. | Xu, LM., et al. 2007. Zhong Xi Yi Jie He Xue Bao. 5: 282-6. PMID: 17498488
- A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. | Zhang, T., et al. 2008. Mol Cancer Ther. 7: 162-70. PMID: 18202019
- Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. | Huang, Y., et al. 2008. Cancer Lett. 264: 101-6. PMID: 18343027
- Tripterine prevents endothelial barrier dysfunction by inhibiting endogenous peroxynitrite formation. | Wu, F., et al. 2009. Br J Pharmacol. 157: 1014-23. PMID: 19508391
- The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. | Sassa, H., et al. 1990. Biochem Biophys Res Commun. 172: 890-7. PMID: 2241977
- Tripterine up-regulates miR-223 to alleviate lipopolysaccharide-induced damage in murine chondrogenic ATDC5 cells. | Li, X., et al. 2019. Int J Immunopathol Pharmacol. 33: 2058738418824521. PMID: 30791741
- Celastrol Attenuates Angiotensin II-Induced Cardiac Remodeling by Targeting STAT3. | Ye, S., et al. 2020. Circ Res. 126: 1007-1023. PMID: 32098592
- Tripterine: A Potential Anti-Allergic Compound. | Zhu, BJ., et al. 2021. Curr Pharm Biotechnol. 22: 159-167. PMID: 32216736
- Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells. | Chen, X., et al. 2020. Theranostics. 10: 10290-10308. PMID: 32929349
- Inflammation-Targeted Celastrol Nanodrug Attenuates Collagen-Induced Arthritis through NF-κB and Notch1 Pathways. | An, L., et al. 2020. Nano Lett. 20: 7728-7736. PMID: 32965124
- [Effects of Tripterine on Adhesion Molecules and Cell Cycle in Human Acute Promyelocytic Leukemia Model Mice]. | Song, DP. and Wu, SY. 2021. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 29: 72-76. PMID: 33554800
- Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis. | Wang, Y. 2021. Inflamm Res. 70: 323-341. PMID: 33559709
- Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis. | Liu, M., et al. 2021. Mol Oncol. 15: 2084-2105. PMID: 33675143
- Celastrol in metabolic diseases: Progress and application prospects. | Xu, S., et al. 2021. Pharmacol Res. 167: 105572. PMID: 33753246
Inhibitor of:
α4-crystallin, β-TrCP, βA4-crystallin, 20S Proteasome α3, 20S Proteasome α7, 4933422H20Rik, Abin-3, ANKRD10, AP1, ASB-11, ASTE1, Bag-2, Bag-3, Bag-5, BAG-6, C4orf30, C5orf25, Cdc23, Cdc26, Cdc37, Cdc37L1, chaperonin containing TCP1 ring complex (CCT), CIP2A, CMG1, COL2A1, CRSP34_Med27, CSN3, CSN7a, D630042P16Rik, DACH1, Dcun1D4, DEME-6, Derlin-1, Derlin-2, DnaJB12, DnaJB3, EG229862, EG434219, EG623459, EG624439, EG624584, FADD, FAM105B, FAM134A_Fam134a, Fbxo12, Fbxo12J, Fbxw13, Fbxw16, FBXW17, Fbxw19, FBXW2, FBXW9, FKBP52, GC-B, GGA2, GrpEL1, H2-Dk, HIF PHD3, HIF-3α, hnRNP A2/B1, hnRNP E2, HRF, HSBP1, HSBP1L1, HSF3, HSFX1, HSFY2, HSP 20, HSP 60, HSP 90, HSPA2, HSPA4L, HSPA6, HSPB7, HSPBAP1, HspBP1, HSPC196, IκB-ζ, I830012O16Rik, IBRDC2, IFIX, IL-17D, IL-23R, IL-33, IRAK-2, Josephin-3, KBTBD11, KLHL11, KLHL35, L7RN6, LAGE-2A, LITAF, MAGE-A5, Malin, MECL-1, MetAP-1, Msx-1, NAIP2, NDUFA (NADH:ubiquinone oxidoreductase subunit), NDUFB (NADH:ubiquinone oxidoreductase subunit), NDUFB11, NEDL1, nemo I, NF-1B, NFκB p50, NFκB p65, NFAT5, NFKBIL2, Nlrp12, NOSTRIN, p100, p105, p47-phox, PDCL2, PDILT, Pellino 3, PHD (peptidyl-proline 4-dioxygenase), Pin1l, PNGase, POT1, prefoldin 1, prefoldin 2, prefoldin 6, PSG1, PSMB11, PSME proteasome activator subunits (PA28), PTGES3L-AARSD1, PYPAF7, QCR10, RelB, RNF133, RNF175, RNF222, Rpn2, SAMD9, Sec61α2, SEL-10, SGTA, Skeletrophin, Skp1, Smurf1, SOCS-2, Sox-6, Sp1, SPATA2, SPP, ST2, SUSP4, TAJ-α, TALL-1, TCP-1 γ, TCP-1 θ, Tenr, TFEC, THP, TIP120B, TLR1, TLR3, TNF-R2, Topo II, Torsin3A, TRADD, TRAF1, TRAF4, TRAF7, Trav9d-1, TRIM31, TRIM40, TRIM45, TSG-6, TTP, UBE1L, UBE4A, Ubr1, UCRC, Uqcr, V1RF1, V1RF2, V1RF3, V1RG6, Xlr3c, Xlr4c, Xlr5c, and ZPBP2.Activator of:
αC-crystallin, 20S Proteasome α1, 20S Proteasome α5, 20S Proteasome β1, 20S Proteasome β2, 26S Proteasome p54, 4933402E13Rik, AGR2, Ataxin-3, BRD2, CD30, CHIP, CIRP, Clusterin, COP1, CRELD2, CUL-7, D630042P16Rik, DnaJA4, DnaJB14, DnaJB5, DnaJC11, DnaJC7, DnaJC9, DTX3L, E330034G19Rik, EDEM2, EG240327, EG432879, EG434219, EG623459, elafin, ENX-1, ERp27, Factor B, FAM62C, FBXO3, FDXACB1, FKBP10, FKBP52, FKBPL, Fn14, GLT8D4, Glucosidase IIα, GOLPH4, GP78-1, GRASP55, GRP 75, GrpEL1, H2-Aa, Herc4, HIF PHD, HSF1, HSF2, HSF3, HSF5, HSP 10, HSP 27, HSP 40, HSP 40-4, HSP 47, HSP 56, HSP 65, HSP 90, HSP 90α, HSPA12B, HSPA1L, HSPA4L, HSPB11, HSPB2, HSPB3, HSPB9, HSPC121, HTPAP, HYPK, IκB-δ, IL-18, IL-1RAcP, IRAK-M, KBTBD5, KDEL ER Marker, KLHL23, LMP7, LOXL1, MAGE-A8, MAN1A2, Mex3a, NEDD4-L, Nrdp1, PCNP, PDI, PLIC-2, prefoldin 3, PROS-30, Proteassemblin, PSMB6, PSMC1, PSMC4, PSMD11, RBM10, reticulocalbin-1, RIPX, RNF122, RNF148, SATB1, Sec62, SETX, Smt3, SOCS-1, SODD, SPC12, SSTK-IP, TCP-1 α, TCP-1 η, TCP-1 ζ, TID-1, TMC5, TNFα-IP 1, TNFα-IP 2, TNFα-IP 8L3, Tollip, TRIAD1, TRIM35, TRIM58, TRIM6, TXNDC1, UBC8, UBE1L2, Ubr3, UFD1, UIP5, UNC45A, UNCL, USP45, UXT, VibH, VSTM1, Ydj1, ZBTB6, ZCSL3, and ZFP319.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Celastrol, Celastrus scandens, 10 mg | sc-202534 | 10 mg | $158.00 |