TMPIT Inhibitors
TMPIT inhibitors constitute a class of chemical compounds that selectively target and inhibit the activity of a specific enzyme or a group of enzymes. The acronym TMPIT generally stands for a particular enzymatic activity or a specific enzyme that these compounds are designed to inhibit, although without specifying the exact enzyme, the description must remain somewhat general. Enzyme inhibitors, like those in the TMPIT class, are molecules that bind to enzymes and decrease their activity. Since enzymes play crucial roles in various biochemical pathways, their inhibition can result in the alteration of a biochemical pathway's dynamics.
The mode of action of TMPIT inhibitors can be diverse. They often function by binding to the active site of an enzyme, thereby preventing the substrate from interacting with that site and proceeding with the catalytic reaction that the enzyme would normally facilitate. Some inhibitors bind reversibly, while others may bind irreversibly, leading to permanent inactivation of the enzyme. The binding of these inhibitors can be competitive, non-competitive, or uncompetitive, depending on whether they directly compete with the substrate for the active site or bind to a different site on the enzyme. This interaction is highly specific and is often a result of the inhibitor's structure, which is designed to closely mimic the enzyme's natural substrate or to fit into its active site with high affinity. The specificity and mode of inhibition are key factors that define the effectiveness and selectivity of TMPIT inhibitors within a complex biological environment where numerous enzymes are simultaneously active.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
Haloperidol is a butyrophenone antipsychotic that antagonizes dopamine D2 receptors, which may reduce dopamine-mediated cellular functions. TMPIT is implicated in intracellular signaling pathways modulated by dopamine, and haloperidol's antagonism could indirectly decrease TMPIT's functional activity by limiting dopamine signaling. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone is a potassium-sparing diuretic that acts as an antagonist of the aldosterone receptor. TMPIT, being part of the intracellular pathways influenced by aldosterone, may have its activity indirectly reduced through the blockade of aldosterone signaling by spironolactone. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, which impacts the PI3K/AKT/mTOR pathway. TMPIT, which can be regulated by mTOR through downstream signaling, may have its function indirectly inhibited due to the suppression of mTOR activity by rapamycin. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that disrupts p38 MAPK-mediated signaling pathways. TMPIT's activity, when it is involved in cellular responses facilitated by p38 MAPK, could be indirectly inhibited by SB203580. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which inhibits the PI3K/AKT pathway. If TMPIT's functional activity is modulated by PI3K signaling, LY294002 can lead to an indirect inhibition of TMPIT by preventing PI3K-driven activation. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is a dopamine antagonist that can indirectly affect TMPIT if it is involved in dopamine-regulated pathways. By blocking dopamine receptors, chlorpromazine may lead to a decrease in TMPIT activity. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $127.00 | 18 | |
Losartan is an angiotensin II receptor antagonist that may inhibit TMPIT indirectly by blocking angiotensin II-mediated signaling pathways, which can influence TMPIT functionality. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways, including those involving inflammatory cytokines. If TMPIT is regulated by such cytokines, curcumin's modulation of these pathways could result in an indirect reduction in TMPIT activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that can disrupt the Rho/ROCK pathway. TMPIT, if associated with this pathway, could have its activity reduced indirectly by the action of Y-27632. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a tyrosine kinase inhibitor that can affect TMPIT indirectly by inhibiting ABL kinases, which may be upstream regulators of TMPIT in certain signaling pathways. | ||||||