TMEM80 Activators
TMEM80 can initiate a variety of intracellular signaling pathways, resulting in its activation. Forskolin directly stimulates adenylyl cyclase, which catalyzes the conversion of ATP to cAMP, a pivotal secondary messenger in cellular signaling. The rise in cAMP levels activates protein kinase A (PKA), which then can phosphorylate TMEM80, leading to its activation. Similarly, IBMX raises cAMP levels but does so by inhibiting phosphodiesterases, the enzymes responsible for the breakdown of cAMP. This inhibition results in sustained PKA activation and subsequent phosphorylation of TMEM80. Another activator, PMA, functions through a different mechanism, activating protein kinase C (PKC), which in turn can phosphorylate TMEM80 if it is within PKC's substrate range.
Diverse cellular signaling pathways involving TMEM80 are influenced by calcium dynamics. Ionomycin, by increasing intracellular calcium concentrations, can activate calmodulin-dependent kinases (CaMK), which may phosphorylate and activate TMEM80. A23187 also modulates calcium levels by acting as a calcium ionophore, potentially triggering calcium-dependent activation of TMEM80. In parallel, the engagement of specific receptors by agonists like Epinephrine and PGE2 leads to G protein-coupled receptor signaling, which often results in increased cAMP levels and PKA activation, providing another route for TMEM80 activation. The activation of TMEM80 can also be influenced by cGMP through the action of Sildenafil, which inhibits phosphodiesterase type 5, leading to elevated cGMP levels and activation of protein kinase G (PKG). Capsaicin, by activating TRPV1 channels, results in calcium influx and the possible activation of TMEM80 via calcium-dependent pathways. Lastly, Dibutyryl-cAMP, a membrane-permeable analog of cAMP, directly activates PKA, and AICAR, by activating AMP-activated protein kinase (AMPK), can lead to the phosphorylation and activation of TMEM80, implicating it in energy-related cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing the production of cyclic AMP (cAMP), a secondary messenger that can lead to the phosphorylation and subsequent activation of various proteins, including TMEM80, via PKA-dependent pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, leading to an increase in cAMP levels, which can enhance the activation of PKA and downstream proteins such as TMEM80 through phosphorylation processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate and activate proteins in related signaling cascades, potentially including TMEM80 if it is a substrate of PKC or part of a PKC-regulated pathway. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calmodulin-dependent kinases (CaMK), possibly leading to the activation of TMEM80 if it is regulated by calcium signaling pathways. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to adrenergic receptors, leading to G protein-coupled receptor signaling cascades that increase cAMP and activate PKA, which could then activate TMEM80 through phosphorylation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) activates its G protein-coupled receptors, triggering signaling pathways that can lead to the activation of downstream proteins, potentially including TMEM80 via EP receptor-mediated cascades. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcimycin (A23187) acts as an ionophore for calcium, which can induce the activation of calcium-dependent pathways, leading to the activation of proteins including TMEM80 if it is part of such pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin acts as a protein synthesis inhibitor but also activates stress-activated protein kinases (SAPKs), which could lead to the activation of TMEM80 if it is responsive to stress signals mediated by these kinases. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates transient receptor potential vanilloid 1 (TRPV1) channels, leading to calcium influx and the activation of downstream calcium-dependent proteins, which might include TMEM80 if it is regulated by calcium-dependent mechanisms. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that directly activates PKA, leading to the phosphorylation and activation of downstream proteins that could include TMEM80 if it is a PKA substrate. | ||||||