TMEM71 Activators
TMEM71 activators are compounds that specifically target the transmembrane protein 71 (TMEM71), aiming to increase its biological activity. TMEM71 is a less characterized member of the transmembrane protein family, which typically spans the lipid bilayer of cells and can be involved in various cellular functions, including signaling, transport, and cellular structure maintenance. The function of TMEM71, like many transmembrane proteins, may be related to the transmission of molecular signals across the cell membrane or the facilitation of interactions between the intracellular and extracellular environments. Activators of TMEM71 are designed to enhance the protein's natural activity, which could involve increasing its expression, stability, or the efficiency of its interactions with other cellular components.
The precise mechanisms through which TMEM71 activators exert their effects could vary, depending on the exact role of TMEM71 in cellular physiology. If TMEM71 is involved in signaling pathways, activators may bind to the protein and induce a conformational change that promotes its interaction with downstream signaling molecules, thus amplifying the signal cascade. Alternatively, if TMEM71's function is associated with the transport of molecules across the membrane, activators might increase the protein's affinity for its substrates or the rate at which it conducts them. To create such activators, a detailed understanding of TMEM71's structure, including its transmembrane domains and any regulatory regions, is essential. Additionally, insights into the cellular pathways and processes with which TMEM71 is associated would be crucial for ensuring that activators are specific to their target and do not inadvertently modulate the activity of other transmembrane proteins with potentially similar structures or functions.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may upregulate TMEM71 by triggering SIRT1 activation, which then enhances the deacetylation process of specific transcription factors bound to the TMEM71 promoter, thus promoting gene transcription. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin could stimulate TMEM71 expression by initiating the AMPK signaling cascade, which enhances mitochondrial biogenesis, potentially leading to the upregulation of TMEM71 as part of a broader cellular adaptation to energy stress. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid might induce TMEM71 transcription by interacting with retinoic acid receptors that bind to retinoic acid response elements in the promoter region of the TMEM71 gene, stimulating its expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is likely to stimulate TMEM71 expression by inhibiting the activation of NF-κB, leading to a decrease in inflammatory signaling and creating a favorable environment for the expression of genes like TMEM71. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate may induce TMEM71 expression by activating antioxidant response elements within the gene's promoter, due to its potent antioxidant properties, thereby enhancing its transcription. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane could enhance TMEM71 transcription by stimulating Nrf2, which then translocates to the nucleus and binds to antioxidant response elements in the regulatory regions of genes such as TMEM71. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Exposure to hydrogen peroxide may lead to the upregulation of TMEM71 as a compensatory mechanism, where cells activate transcription of mitochondrial genes to counteract oxidative damage. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol could elevate TMEM71 expression through the vitamin D receptor, which, upon ligand binding, binds to vitamin D response elements in the TMEM71 gene promoter, stimulating its transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium may stimulate the expression of TMEM71 by inhibiting GSK-3β, thereby enhancing Wnt signaling which can lead to increased transcriptional activity of genes involved in neuronal health, including TMEM71. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone could prompt the upregulation of TMEM71 by activating PPAR-γ, which recognizes PPAR response elements in the TMEM71 gene promoter, leading to an increase in its gene expression. | ||||||