TMEM196 Inhibitors
TMEM196 inhibitors are a category of chemical entities designed to interact with the transmembrane protein 196 (TMEM196), a protein that is encoded by the TMEM196 gene in humans. This protein is a member of a broader class of transmembrane proteins, which typically span the cellular membrane and are involved in a variety of cellular processes such as signal transduction, cell adhesion, and the transport of substances in and out of the cell. TMEM196 inhibitors specifically aim to modulate the activity of the TMEM196 protein, affecting its normal function within the cellular environment. The precise biological function of TMEM196 is not completely understood, but like other transmembrane proteins, TMEM196 is presumed to play a role in the complex web of cellular signaling pathways and mechanisms.
The development and study of TMEM196 inhibitors involve an intricate understanding of molecular chemistry and biology. These inhibitors are small molecules that can bind to the TMEM196 protein with high specificity. The binding of these inhibitors to TMEM196 can result in changes to the protein's conformation, potentially altering its interaction with other cellular components or its overall stability within the cell membrane. The structural design of TMEM196 inhibitors is typically based on the known or predicted three-dimensional structure of the TMEM196 protein, often utilizing computational models and empirical data to create molecules that fit within certain regions of the protein, such as active sites or allosteric sites. This fitting is not a simple lock-and-key mechanism; it often requires consideration of dynamic aspects of both the protein and the inhibitor, including conformational flexibility and the presence of competing molecules in the cellular environment. Research into TMEM196 inhibitors involves a multidisciplinary approach, incorporating techniques from fields such as organic chemistry, biochemistry, structural biology, and computational modeling to refine the specificity and efficacy of these molecular interactions.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of phosphoinositide 3-kinases (PI3K), LY294002 can indirectly reduce the activity of TMEM196 by affecting the PI3K/AKT signaling pathway, which is involved in cell survival and proliferation. Reduced PI3K activity leads to lower AKT phosphorylation, potentially affecting TMEM196 expression or function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of mitogen-activated protein kinase kinases (MEK1/2), U0126 can indirectly affect TMEM196 by inhibiting the ERK pathway, which plays a role in cell cycle regulation and differentiation. Inhibition of MEK1/2 prevents the activation of downstream ERK, potentially altering TMEM196 activity related to these cellular processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A pyridinyl imidazole compound that inhibits p38 MAP kinase, SB203580 can indirectly influence TMEM196 by modulating the p38 MAPK signaling pathway involved in inflammation and stress response. By blocking p38 MAPK, the compound may affect TMEM196's role in these pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
A macrolide compound that inhibits mammalian target of rapamycin (mTOR), Rapamycin can indirectly decrease TMEM196 activity by impacting the mTOR signaling pathway, which regulates cell growth, proliferation, and survival. Inhibition of mTOR could affect TMEM196's function related to these cellular processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A synthetic compound that specifically inhibits MEK, PD98059 can indirectly affect TMEM196 by inhibiting the MEK/ERK pathway, which is implicated in cell proliferation and differentiation. This inhibition may impact TMEM196's involvement in these cellular processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An anthrapyrazolone inhibitor of c-Jun N-terminal kinase (JNK), SP600125 can indirectly decrease TMEM196 activity by affecting the JNK signaling pathway involved in apoptosis and cellular stress responses. Inhibiting JNK may influence TMEM196's role in these processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A steroidal metabolite that acts as a potent inhibitor of PI3K, Wortmannin can reduce the activity of TMEM196 indirectly by affecting the PI3K/AKT signaling pathway, thereby impacting processes like cell growth and survival where TMEM196 may play a role. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A selective inhibitor of the Rho-associated, coiled-coil containing protein kinase (ROCK), Y-27632 can indirectly affect TMEM196 by influencing the Rho/ROCK pathway, which is involved in cytoskeletal dynamics and cell migration. This may alter TMEM196's activity in related cellular processes. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A selective inhibitor of Src family tyrosine kinases, PP2 can indirectly decrease TMEM196 activity by modulating the Src signaling pathway, which is implicated in various cellular processes including proliferation, differentiation, and survival. This modulation may impact TMEM196's function. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
A selective inhibitor of BMP signaling, Dorsomorphin can indirectly reduce TMEM196 activity by affecting the BMP pathway, which is involved in embryonic development and cellular differentiation. Inhibition of BMP signaling may impact TMEM196's role in these processes. | ||||||