TMEM117 Inhibitors
Chemical inhibitors of TMEM117 can impede the protein's function through a variety of mechanisms that target its association with cellular membranes or its role in signaling pathways. Phloretin disrupts TMEM117 by interfering with its interaction with cellular membranes, possibly altering the dynamics or the lipid composition essential for its proper localization or activity. Similarly, Chlorpromazine affects membrane integrity and fluidity, which could impair TMEM117's membrane-associated functions. Progesterone and Tamoxifen, through their interactions with membrane-bound proteins and the lipid environment, can alter the membrane association of TMEM117 or affect the microenvironment necessary for its functional conformation. Genistein inhibits TMEM117 by targeting protein tyrosine kinases, which may affect the phosphorylation status of TMEM117 or proteins in close interaction with it.
Verapamil and Diltiazem, both calcium channel blockers, inhibit TMEM117 by altering calcium homeostasis, a critical factor for the protein's role in calcium-dependent signaling pathways. Nifedipine, another agent in this class, also modulates calcium signaling, which is likely to affect TMEM117's function. Quinidine influences cellular excitability and signaling by inhibiting voltage-gated sodium channels, which can disrupt TMEM117 if it is functionally connected to sodium-dependent processes. Haloperidol, by disrupting dopamine signaling pathways, may indirectly affect TMEM117's role related to ion channel activity and membrane dynamics. Amiodarone alters the lipid environment by impacting phospholipid metabolism and disrupting lipid bilayers, which can inhibit TMEM117. Lastly, Ibuprofen affects the production of prostaglandins and other lipid signaling molecules, which could be crucial for TMEM117's functional role in cell signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $64.00 $255.00 | 13 | |
Phloretin is a dihydrochalcone compound that can inhibit the activity of TMEM117 by impeding its potential interaction with cellular membranes. As a small molecule known to disrupt various membrane-associated functions, phloretin can alter the membrane dynamics or lipid composition required for TMEM117's proper localization or function. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine, a cationic amphiphilic drug, can inhibit TMEM117 by disrupting membrane integrity and fluidity, potentially impairing the protein’s membrane-associated functions. It may also interfere with intracellular trafficking processes necessary for TMEM117's operational role in the cell. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone interacts with membrane-bound proteins and lipid environments, which could inhibit TMEM117 by altering its membrane association or by affecting the microenvironment necessary for its functional conformation and activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, can inhibit protein tyrosine kinases, potentially impacting the phosphorylation status of proteins closely interacting with TMEM117 or the phosphorylation of TMEM117 itself, thus inhibiting its function. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that can inhibit TMEM117 by altering calcium homeostasis within the cell, which might be critical for TMEM117's role in calcium-dependent signaling pathways or cellular processes. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $104.00 | 3 | |
Quinidine can inhibit voltage-gated sodium channels, affecting cellular excitability and signaling, which could inhibit TMEM117 if it is functionally linked to sodium-dependent processes or electrochemical gradients. | ||||||
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
Haloperidol can inhibit TMEM117 by disrupting dopamine signaling pathways; since dopamine receptors can modulate ion channel activity and membrane dynamics, haloperidol may indirectly impair TMEM117's function related to these processes. | ||||||
Amiodarone | 1951-25-3 | sc-480089 | 5 g | $318.00 | ||
Amiodarone affects phospholipid metabolism and can disrupt lipid bilayers, which can inhibit TMEM117 by altering the lipid environment that is essential for its proper localization or activity within the membrane. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem, a calcium channel blocker, can inhibit TMEM117 by modulating calcium influx, potentially affecting calcium-dependent regulatory mechanisms that TMEM117 may be involved in. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), can inhibit TMEM117 by altering the production of prostaglandins or other lipid signaling molecules that could be crucial for TMEM117's functional role in cell signaling or inflammation response pathways. | ||||||