TMEM107 Inhibitors

TMEM107 inhibitors target various aspects of cellular physiology that can impact the activity of TMEM107 on a functional level. Compounds like Genistein, W-7 Hydrochloride, and LY294002 act on signaling pathways by inhibiting tyrosine kinases, antagonizing calmodulin, and blocking phosphoinositide 3-kinases (PI3K), respectively. These actions can alter downstream pathways, leading to changes in the activity or expression of transmembrane proteins including TMEM107.

Amiloride and Ouabain work by altering ion transport across cellular membranes, which is a fundamental process affecting the function of many membrane proteins. Brefeldin A, Dynasore, and Endosidin 2 are involved in the inhibition of vesicle trafficking, which is crucial for the proper localization and turnover of membrane proteins such as TMEM107. Ionomycin and Niflumic Acid disrupt ion homeostasis, which is essential for the activity of ion-sensitive transmembrane proteins. DIDS and Monensin alter the ion balance across the membrane, impacting the function of transmembrane proteins by changing the electrochemical gradient.