TMEM106B Activators
TMEM106B Activators belong to a class of chemical compounds that specifically target and modulate the activity of the transmembrane protein 106B (TMEM106B), which is primarily located in the endosomal-lysosomal system of cells. TMEM106B is a relatively recently discovered protein that has garnered significant attention due to its association with various neurodegenerative diseases, particularly frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). These activators are designed to influence the function of TMEM106B and, by extension, impact the underlying cellular processes linked to the pathogenesis of these disorders.
The precise mechanism of action of TMEM106B Activators may vary among different compounds, but their primary objective is to modulate the expression or activity of TMEM106B. This modulation can influence the sorting and trafficking of specific proteins within the endosomal-lysosomal system, which is crucial for the maintenance of cellular homeostasis and protein degradation. Dysregulation of this system is implicated in the accumulation of misfolded proteins, such as tau and TDP-43, which are hallmark features of FTLD and AD. By targeting TMEM106B, these activators may help restore the normal functioning of the endosomal-lysosomal system,
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine increases lysosomal acidification, potentially activating TMEM106B's function within the endosomal-lysosomal system. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Hydroxychloroquine, similar to chloroquine, increases lysosomal acidification, potentially activating TMEM106B's function within the endosomal-lysosomal system. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 increases lysosomal acidification, directly activating TMEM106B by altering lysosomal pH and potentially disrupting the endosomal-lysosomal system. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin activates autophagy, indirectly increasing TMEM106B as it interacts with lysosomal and autophagic processes. TMEM106B is associated with regulating autophagy. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine has been studied for its effects on endocytic trafficking processes, potentially activating TMEM106B if it activates the endosomal trafficking pathways where TMEM106B is located. | ||||||