Titin Activators
The chemical class of Titin activators constitutes a diverse array of compounds that finely tune Titin's function within the sarcomere, ultimately amplifying its pivotal role in governing sarcomere dynamics and contractility. Among them, NAD+ emerges as a direct activator of Titin, participating in cellular redox reactions and influencing Titin through post-translational modifications, such as SIRT1-mediated deacetylation. This modification augments Titin's functionality, thereby fostering improved sarcomere contractility. Polydatin and Salidroside, functioning as direct Titin activators, operate through the activation of AMP-activated protein kinase (AMPK). By triggering AMPK activation, these compounds enhance Titin phosphorylation, facilitating its engagement in sarcomere dynamics and contractility. Notably, these activators establish a direct connection between cellular energy status and Titin function.
AICAR, an indirect activator, plays a pivotal role in activating AMPK, thereby influencing Titin phosphorylation and enhancing sarcomere dynamics. Resveratrol, acting as an indirect Titin activator, engages in SIRT1-mediated deacetylation, amplifying Titin's function and promoting sarcomere dynamics. Additionally, Forskolin, elevating cAMP levels, and A769662, activating AMPK, provide alternative indirect pathways, intensifying Titin phosphorylation and enhancing sarcomere contractility. Indirect Titin activators GW501516, through PPARδ activation, and Metformin, through AMPK activation, further contribute to enhanced Titin phosphorylation, ultimately improving sarcomere dynamics. Leucine, acting through the mTOR pathway, and Curcumin, modulating PI3K/AKT and AMPK, introduce additional diversity into the array of pathways through which Titin activation is achieved. In conclusion, these Titin activators serve as invaluable tools for delving into the intricate molecular mechanisms that underlie sarcomere dynamics and contractility. Their diverse modes of action underscore the complexity of the regulatory network influencing Titin function within the sarcomere.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ functions as a direct Titin activator by participating in cellular redox reactions. The interaction with Titin may involve post-translational modifications, such as SIRT1-mediated deacetylation, enhancing Titin's function and promoting sarcomere dynamics. | ||||||
Polydatin | 65914-17-2 | sc-203203 | 10 mg | $92.00 | 5 | |
Polydatin serves as a direct Titin activator through the activation of AMP-activated protein kinase (AMPK). AMPK activation enhances Titin phosphorylation and promotes its interaction with other sarcomeric proteins, contributing to improved sarcomere contractility and function. | ||||||
Salidroside | 10338-51-9 | sc-472942 | 50 mg | $360.00 | 1 | |
Salidroside acts as a direct Titin activator by influencing the AMP-activated protein kinase (AMPK) pathway. AMPK activation enhances Titin phosphorylation, facilitating its role in sarcomere dynamics and contractility. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR serves as an indirect Titin activator by activating AMP-activated protein kinase (AMPK). AMPK activation enhances Titin phosphorylation, facilitating its role in sarcomere dynamics and contractility. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol acts as an indirect Titin activator through the activation of SIRT1. SIRT1-mediated deacetylation enhances Titin function and promotes sarcomere dynamics. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an indirect Titin activator that acts through the activation of adenylate cyclase and the increase in cAMP levels. Elevated cAMP levels enhance Titin phosphorylation and improve its function in sarcomere dynamics and contractility. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662 functions as an indirect Titin activator by activating AMP-activated protein kinase (AMPK). AMPK activation enhances Titin phosphorylation, facilitating its role in sarcomere dynamics and contractility. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516 acts as an indirect Titin activator through the activation of PPARδ. PPARδ activation enhances Titin phosphorylation and improves its function in sarcomere dynamics and contractility. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin is an indirect Titin activator that acts through the activation of AMP-activated protein kinase (AMPK). AMPK activation enhances Titin phosphorylation, facilitating its role in sarcomere dynamics and contractility. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
Leucine is an indirect Titin activator that acts through the mTOR pathway. Activation of mTOR enhances Titin phosphorylation and promotes its interaction with other sarcomeric proteins, contributing to improved sarcomere function and contractility. | ||||||