TIEG2 Activators
The TIEG2 activators belong to a distinctive chemical class known for their ability to modulate the transcriptional activity of the transforming growth factor-beta (TGF-β)-inducible early gene 2 (TIEG2). TIEG2, also recognized as KLF11 (Kruppel-like factor 11), is a member of the Kruppel-like family of zinc finger transcription factors that play a pivotal role in cellular processes such as apoptosis, cell cycle regulation, and differentiation. The activators of TIEG2 operate at the molecular level by interacting with specific elements within the gene's promoter region, thereby influencing its expression. These compounds have been identified as potent agents capable of fine-tuning the intricate balance of cellular responses mediated by TIEG2.
Structurally, TIEG2 activators exhibit a diverse range of chemical scaffolds, showcasing the versatility within this class. Despite this structural diversity, the commonality among these compounds lies in their ability to elicit a biological response through the upregulation or downregulation of TIEG2 gene expression. Research efforts have been directed toward understanding the nuanced mechanisms through which these activators exert their effects on TIEG2, shedding light on applications in various cellular contexts. The exploration of TIEG2 activators has opened up avenues for unraveling the intricate signaling pathways governed by TIEG2, providing valuable insights into the broader landscape of cellular regulation and gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound that is known to activate sirtuins, particularly SIRT1. Activation of SIRT1 can enhance the functional activity of TIEG2 as it is involved in the regulation of several transcription factors and coactivators. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural phenol compound that has been shown to activate the JNK pathway. The JNK pathway has been linked to the activation of TIEG2, playing significant roles in stress-induced responses. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II inhibitor. By inhibiting topoisomerase II, DNA damage is induced, leading to the activation of p53. TIEG2 is a downstream effector of p53 and can therefore be indirectly activated. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound that can activate the NRF2 pathway. This pathway is known to regulate the expression of antioxidant proteins and can indirectly lead to the activation of TIEG2. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a metabolite of vitamin A that acts to regulate the retinoic acid receptor (RAR). RAR activation can influence the expression of TIEG2, thereby enhancing its activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase leading to an increase in cAMP levels. Increased cAMP can enhance the activity of TIEG2 through the CREB pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that can activate SIRT1. As mentioned above, activation of SIRT1 can enhance the functional activity of TIEG2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. By inhibiting mTOR, autophagy is induced which can lead to the activation of TIEG2, as TIEG2 has been implicated in the regulation of autophagy. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin is a topoisomerase II inhibitor. By the same mechanism as etoposide, it can lead to the activation of TIEG2. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $92.00 $256.00 | 5 | |
Zoledronic acid is a bisphosphonate that can lead to the activation of the ERK pathway. The ERK pathway has been implicated in the regulation of TIEG2. | ||||||