TIAR Activators
The chemical class of TIAR activators encompasses a diverse array of compounds that exert their influence on TIAR expression through various mechanisms, thereby unraveling the intricate regulation of this RNA-binding protein. TIAR, a vital member of the T-cell intracellular antigen (TIA) family, assumes a pivotal role in post-transcriptional gene regulation, particularly in the realms of stress responses and cellular homeostasis. A noteworthy ensemble of TIAR activators includes Actinomycin D, Triptolide, 5-Fluorouracil (5-FU), Cordycepin, α-Amanitin, BMH-21, Triamterene, Actinomycin X2, Homoharringtonine, 6-Thioguanine, Mycophenolic Acid (MPA), and α-Amanitin Derivative (AMA). These compounds stand out for their capacity to modulate TIAR indirectly, primarily by interfering with RNA synthesis, either through the inhibition of RNA polymerase II or disruption of nucleotide metabolism. Consequently, the reduced global RNA production facilitates increased TIAR availability, promoting its binding to target transcripts.
Actinomycin D and Actinomycin X2, both inhibitors of RNA synthesis, exemplify how a global perturbation of transcription can significantly impact TIAR expression. Triptolide and BMH-21, selective inhibitors of RNA polymerase II, offer more targeted approaches to explore TIAR modulation, while Triamterene, a diuretic, underscores the intricate connection between cellular stress responses and TIAR regulation. Homoharringtonine and Mycophenolic Acid (MPA), recognized as translation and nucleotide biosynthesis inhibitors, respectively, shed light on the cross-talk between translation dynamics and nucleotide metabolism in shaping TIAR expression. These compounds collectively provide unique insights into the multifaceted regulatory network governing TIAR, paving the way for a nuanced understanding of TIAR function across diverse cellular contexts. The chemical class of TIAR activators thus emerges as a valuable toolkit for researchers delving into the complexities of post-transcriptional gene regulation, offering a spectrum of compounds to dissect TIAR's role in cellular processes with precision and depth.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D, an RNA synthesis inhibitor, indirectly activates TIAR. By inhibiting RNA polymerase, it decreases overall RNA production, leading to an upregulation of TIAR due to decreased competition for binding to RNA transcripts. This indirect activation highlights the dependence of TIAR on RNA dynamics, and Actinomycin D serves as a tool to modulate TIAR expression through global RNA synthesis inhibition. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide, a natural product, indirectly activates TIAR by inhibiting RNA polymerase II. This inhibition reduces the synthesis of RNA, resulting in increased availability of TIAR for binding to target transcripts. Triptolide's indirect activation of TIAR underscores the intricate relationship between transcriptional dynamics and TIAR expression, offering insights into potential pathways to modulate TIAR levels. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil (5-FU), a pyrimidine analog, indirectly activates TIAR. By disrupting RNA synthesis, it leads to decreased competition for TIAR binding, resulting in its indirect activation. The modulation of TIAR by 5-FU highlights the interplay between nucleotide metabolism and RNA-binding proteins, offering a pharmacological avenue to influence TIAR expression through perturbation of RNA synthesis pathways. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin, an adenosine analog, indirectly activates TIAR by interfering with mRNA synthesis. Its incorporation into nascent RNA strands leads to premature termination, reducing RNA production and increasing TIAR availability for binding. Cordycepin's indirect activation of TIAR reveals the sensitivity of TIAR expression to alterations in RNA synthesis, providing a chemical means to study and modulate TIAR levels in cellular contexts. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin, a potent RNA polymerase II inhibitor, indirectly activates TIAR. Its inhibition of transcription results in reduced competition for TIAR binding, leading to increased TIAR availability. α-Amanitin's indirect activation of TIAR sheds light on the intricate relationship between transcriptional processes and the regulation of RNA-binding proteins, offering a pharmacological tool to explore and manipulate TIAR expression. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
BMH-21, a selective RNA polymerase II inhibitor, indirectly activates TIAR. By inhibiting RNA synthesis, it enhances TIAR availability for binding to target transcripts. BMH-21's indirect activation of TIAR underscores the intricate connection between transcriptional dynamics and RNA-binding proteins, providing a chemical tool to explore and modulate TIAR expression in the context of altered RNA synthesis pathways. | ||||||
Triamterene | 396-01-0 | sc-213103A sc-213103 | 1 g 5 g | $22.00 $54.00 | ||
Triamterene, a diuretic, indirectly activates TIAR by disrupting RNA synthesis. Through its inhibitory effect on RNA polymerase II, it reduces global RNA production, leading to increased TIAR binding. Triamterene's indirect activation of TIAR highlights the sensitivity of TIAR expression to changes in RNA dynamics, offering a pharmacological approach to explore and manipulate TIAR levels in cellular systems. | ||||||
Actinomycin V | 18865-48-0 | sc-507379 | 1 mg | $450.00 | ||
Actinomycin V, an RNA synthesis inhibitor, indirectly activates TIAR. By inhibiting RNA polymerase, it decreases overall RNA production, leading to increased TIAR availability for binding to target transcripts. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
Homoharringtonine, a translation inhibitor, indirectly activates TIAR. By inhibiting protein synthesis, it influences the availability of TIAR for binding to target mRNAs. Homoharringtonine's indirect activation of TIAR unveils the intricate connection between translation dynamics and the regulation of RNA-binding proteins, offering a pharmacological approach to explore and manipulate TIAR levels in the context of altered protein synthesis. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
6-Thioguanine, a purine analog, indirectly activates TIAR. By disrupting nucleotide metabolism and RNA synthesis, it enhances TIAR availability for binding to target transcripts. 6-Thioguanine's indirect activation of TIAR reveals the sensitivity of TIAR expression to alterations in nucleotide dynamics, providing a chemical means to study and modulate TIAR levels in cellular contexts influenced by perturbed purine metabolism. | ||||||