TFE3 Activators
TFE3 Activators comprise a diverse group of chemical compounds known for their ability to induce the expression of Transcription Factor E3 (TFE3), a significant transcription factor involved in various cellular processes. This chemical class is not uniform in its structure or origin, encompassing a wide range of substances with varying chemical properties and mechanisms of action. These activators influence TFE3 expression through multiple cellular pathways, demonstrating the complexity and interconnected nature of cellular regulatory systems. The commonality among these activators lies in their capacity to modulate TFE3, a protein that plays a key role in gene regulation, lysosomal biogenesis, autophagy, and metabolic regulation.
The mechanisms through which TFE3 Activators function are diverse and often involve key cellular signaling pathways. For example, some activators work by inhibiting the mTOR pathway, a crucial regulator of cell growth, proliferation, and survival. This inhibition can lead to the upregulation of TFE3 as part of the cell's response to changes in metabolic conditions or stress. Other compounds might act by inducing cellular stress responses, such as oxidative stress, energy deprivation, or disruption of lysosomal functions. These stressors can trigger a cascade of regulatory events leading to the increased expression of TFE3. Additionally, certain TFE3 Activators might interact with cellular receptors or enzymes, thereby indirectly influencing the expression of TFE3. These interactions showcase the activators' roles in the fine-tuning of cellular functions and stress responses. Despite the varied mechanisms, all TFE3 Activators ultimately converge on the modulation of TFE3, highlighting its central role in cellular homeostasis and the regulation of gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin may induce TFE3 expression by inhibiting the mTOR pathway, which is known to regulate various cellular processes including autophagy and metabolism. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1, like rapamycin, inhibits the mTOR pathway, potentially increasing TFE3 expression as part of the cellular response to altered metabolic conditions. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin is believed to activate AMPK, which can indirectly influence TFE3 expression by modulating cellular energy status. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may impact TFE3 expression through its action on sirtuins and AMPK, influencing cellular stress responses and metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways, potentially affecting TFE3 expression as part of its broad regulatory effects on cellular function. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
As a glucose analog, 2-Deoxy-D-glucose might induce TFE3 expression by mimicking energy stress, thereby activating cellular stress response pathways. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1, an inhibitor of the vacuolar-type H+-ATPase, may affect lysosomal function, potentially influencing TFE3 expression due to its role in lysosomal biogenesis. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine, by affecting lysosomal acidity, could alter cellular autophagic processes, potentially leading to changes in TFE3 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin may influence TFE3 expression through its effects on oxidative stress and AMPK activation, which are part of cellular defense mechanisms. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine, known to inhibit autophagy, might induce TFE3 expression as a compensatory response to impaired autophagic flux. | ||||||