TET1 Inhibitors
Common TET1 Inhibitors include, but are not limited to 5-Aza-2′-Deoxycytidine CAS 2353-33-5, RG 108 CAS 48208-26-0, Mithramycin A CAS 18378-89-7, Tetrahydrouridine CAS 18771-50-1 and (-)-Epigallocatechin Gallate CAS 989-51-5.
TET1 inhibitors constitute a distinctive class of compounds that modulate the function of the TET1 enzyme, a key player in the field of epigenetics. TET1, also known as ten-eleven translocation 1, operates by catalyzing the conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), a pivotal step in the intricate process of DNA demethylation. These inhibitors are meticulously designed to engage with specific binding sites within TET1's catalytic domain, disrupting its enzymatic activity and influencing the dynamic balance between DNA methylation and demethylation events. The manipulation of TET1 activity through these inhibitors offers a unique avenue to dissect the complexities of epigenetic regulation, unveiling insights into the ways in which DNA methylation patterns are linked to gene expression profiles.
The investigation of TET1 inhibitors delves into their targeted interaction with the TET1 enzyme, unraveling the intricate mechanisms underlying epigenetic modifications. The inhibition of TET1 function using these compounds provides a valuable tool to elucidate the impact of altered DNA demethylation dynamics on gene regulation and cellular behavior. As epigenetic processes play a fundamental role in various biological processes, TET1 inhibitors offer a gateway to explore the intricate interplay between DNA modifications and gene expression patterns. By deciphering the effects of TET1 inhibition, researchers can gain deeper insights into the regulatory networks that govern cellular phenotypes and gene transcription, contributing to a broader understanding of epigenetic control mechanisms.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine (decitabine) is a nucleoside analog that might inhibit TET1 by incorporating into DNA during replication and trapping TET1, preventing DNA demethylation. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a small molecule that might inhibit TET1 by binding to its active site, potentially interfering with its enzymatic activity and DNA demethylation. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A is an antibiotic that might inhibit TET1 by binding to GC-rich DNA regions, potentially affecting its binding and demethylation activity. | ||||||
Tetrahydrouridine | 18771-50-1 | sc-204339 | 10 mg | $416.00 | 1 | |
Tetrahydrouridine is a ribonucleoside analog that might inhibit TET1 by interfering with its binding to RNA, potentially affecting its function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a natural compound that might inhibit TET1 by affecting its enzymatic activity and DNA demethylation processes. | ||||||