TET1 Activators
Common TET1 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, 5-Azacytidine CAS 320-67-2, Fluorouracil CAS 51-21-8, L-Ascorbic acid, free acid CAS 50-81-7 and Resveratrol CAS 501-36-0.
TET1, or Ten-Eleven Translocation 1, is a crucial enzyme involved in the epigenetic regulation of DNA. It functions primarily by catalyzing the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), a modification known to play a significant role in DNA demethylation. This process is pivotal for the regulation of gene expression, cellular differentiation, and the maintenance of cellular identity. As part of the TET family, which also includes TET2 and TET3, TET1 has a vital role in early embryonic development, stem cell pluripotency, and the suppression of tumorigenesis. The enzyme's action is not just restricted to the conversion of 5mC to 5hmC; it can further oxidize 5hmC to produce 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), contributing to a dynamic landscape of DNA modifications.
TET1 activators are chemical entities designed to promote or enhance the enzymatic activity of TET1. These activators might function by stabilizing the enzyme, facilitating its binding to DNA, or increasing its affinity for its co-factors. By amplifying the natural activity of TET1, these activators can influence the epigenetic state of the cell, leading to changes in gene expression patterns. Given the importance of DNA methylation and demethylation in cellular processes, the use of TET1 activators could provide a mechanism to modulate these epigenetic marks, impacting a range of biological processes, from development to cellular response to environmental cues. The intricate balance of DNA modifications, including those introduced by TET1, underscores the importance of understanding and harnessing the capabilities of TET1 activators in various biological contexts.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Involved in cellular differentiation and development, retinoic acid might upregulate TET1 expression to facilitate DNA demethylation processes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that could increase TET1 expression as a compensatory mechanism to regulate DNA methylation levels. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Can influence DNA methylation patterns; might upregulate TET1 to modulate epigenetic modifications. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Acts as a cofactor for TET enzymes, enhancing their activity; might indirectly upregulate TET1 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Known for modulating various cellular pathways, it might influence TET1 expression in the context of epigenetic regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
With its anti-inflammatory and antioxidant properties, curcumin might influence epigenetic regulators, including TET1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that might modulate DNA methylation patterns, potentially influencing TET1 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A soy isoflavone that can influence epigenetic marks, potentially upregulating TET1 expression. | ||||||
Allyl disulfide | 2179-57-9 | sc-252359 | 25 g | $80.00 | ||
Found in garlic, DADS might modulate epigenetic processes, potentially affecting TET1 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Known to influence epigenetic pathways, sulforaphane might modulate TET1 expression. | ||||||