Adenosine deaminase domain containing 1 (ADAD1) is a protein encoded by the ADAD1 gene in humans. While the full extent of its function is not completely understood, it is known to belong to the adenosine deaminase (ADA) family of enzymes, which play a critical role in purine metabolism. These enzymes catalyze the deamination of adenosine, converting it to inosine, and are integral in the turnover of nucleic acids in tissues.
ADAD1 is thought to have a specialized function due to its domain structure that is distinct from other ADA enzymes, suggesting a unique role in cellular metabolism. Its expression and activity are likely important for maintaining the balance of adenosine and deoxyadenosine levels in cells, which is crucial for numerous physiological processes, including signal transduction, metabolic regulation, and possibly neurotransmission.The precise mechanisms of ADAD1's function and regulation, its tissue distribution, and its physiological and pathological roles remain areas of active research. Understanding ADAD1's activity could provide insights into various biological processes and reveal novel targets for diseases where purine metabolism is disrupted
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