TCP11 Inhibitors
TCP11 inhibitors pertain to a category of chemical entities that interact with a specific protein known as testis-expressed protein 11, or TCP11. This protein is part of a larger family of proteins that are encoded by the t-complex on chromosome 17 and are implicated in a variety of cellular processes, particularly those linked to reproductive biology. TCP11 itself is involved in the intricate mechanisms of cell-cell recognition and adhesion, which are essential during the fertilization process. Inhibitors targeting TCP11 are characterized by their ability to bind to this protein and modulate its normal activity, thereby affecting its role in cellular functions. The mode of action of these inhibitors may involve direct interaction with the TCP11 active site, or they may induce conformational changes in the protein structure that alter its function. The diverse structures of these compounds reflect the complexity of their interaction with the protein and the sophisticated chemistry required to achieve selectivity and potency.
The design and synthesis of TCP11 inhibitors require a thorough understanding of protein chemistry and structure-function relationships. Given that TCP11 is a naturally occurring protein with specific biological roles, inhibitors must be crafted to ensure they precisely target this protein without interfering with other proteins or cellular mechanisms-a challenge that calls for precision in molecular design. The chemical makeup of these inhibitors can vary significantly, with each inhibitor having a unique set of molecular features that define its interaction with TCP11. These features are meticulously engineered to ensure the compound can effectively bind to the protein and exert the desired effect on its activity. The development of such inhibitors is a multidisciplinary endeavor, integrating insights from biochemistry, molecular biology, and organic chemistry to create molecules that can selectively and effectively modulate the activity of TCP11.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can increase the acetylation of histones, leading to alterations in chromatin structure and affecting gene expression. As TCP11's function could be regulated by chromatin remodeling, this chemical may indirectly inhibit TCP11 by altering the expression levels or accessibility of the gene. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that impairs the MAPK/ERK signaling pathway. If TCP11 is downstream of this pathway, inhibition by PD98059 would lead to decreased activity of TCP11 due to reduced phosphorylation events that might be critical for TCP11's function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that blocks the PI3K/Akt signaling pathway, potentially reducing the phosphorylation of downstream proteins. If TCP11 activity is modulated by PI3K/Akt signaling, this inhibitor could decrease TCP11's functional activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor which could disrupt inflammatory signaling pathways. If TCP11 is involved in these pathways or regulated by them, inhibition by SB203580 might lead to a decrease in TCP11 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that affects the actin cytoskeleton dynamics. As the cytoskeleton can regulate various cellular processes including those that may involve TCP11, this inhibitor could indirectly lead to the inhibition of TCP11's function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can affect cell growth and proliferation. If TCP11 plays a role in these processes, rapamycin could inhibit its function by impacting the regulatory pathways in which TCP11 participates. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that prevents the activation of MAPK/ERK pathway. If TCP11 is involved in this pathway, U0126 could reduce its activity by inhibiting upstream signaling events required for TCP11's function. | ||||||
WZ 4002 | 1213269-23-8 | sc-364655 sc-364655A | 10 mg 50 mg | $180.00 $744.00 | 1 | |
WZ4002 is an EGFR inhibitor that could potentially downregulate signaling pathways that may affect TCP11 activity if it relies on EGFR-mediated signaling for its function. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is another EGFR inhibitor that, by blocking EGFR tyrosine kinase activity, may downregulate signaling pathways that regulate TCP11 activity, thereby potentially inhibiting its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a JNK inhibitor that can interfere with stress-activated protein kinase signaling pathways. If TCP11's function is modulated by such stress responses, this inhibitor could lead to decreased activity of TCP11. | ||||||