TBC1D13 Activators

TBC1D13 activators typically function through modulation of pathways that affect endosomal sorting and trafficking, emphasizing the protein's GAP activity for cellular homeostasis. For example, Wortmannin and LY294002, as PI3K inhibitors, block a pathway crucial for endosomal maturation, thereby making TBC1D13's role more vital in the cellular trafficking system. This type of chemical interference thus results in increased demand for TBC1D13's role in routing endosomal cargoes.

Similarly, agents like U0126 and Dynasore, by inhibiting MEK1/2 and Dynamin respectively, disrupt endosomal sorting pathways and thus necessitate the role of TBC1D13 in such processes. Bafilomycin A1 and EIPA, which interfere with endosomal acidification, also highlight the importance of TBC1D13 in sorting and trafficking operations. Chloroquine, by affecting endosomal pH, necessitates TBC1D13's involvement in trafficking, as do 3-MA and Rapamycin by their influence on autophagy and mTOR signaling respectively. Pitstop 2 and Alsterpaullone add further layers of complexity by affecting endocytosis and cell cycle, respectively, thereby broadening the role of TBC1D13 in cellular trafficking.