Talin-1 Inhibitors
Talin-1 inhibitors belong to a chemical class designed to specifically target the protein talin-1. Talin-1 is a key cytoskeletal protein that plays a crucial role in mediating cell adhesion and signal transduction. It is involved in linking integrin receptors on the cell surface to the actin cytoskeleton within the cell. This connection is essential for various cellular processes, including cell migration, tissue development, and mechanotransduction – the conversion of mechanical forces into biochemical signals.
By inhibiting the function of talin-1, these compounds disrupt the interaction between integrins and the cytoskeleton, affecting cell adhesion and migration. This disruption can lead to changes in cell behavior and impact processes like wound healing, tissue remodeling, and immune response. The study of talin-1 inhibitors provides insights into the intricate mechanisms of cell adhesion and its influence on cellular functions, shedding light on fundamental aspects of cell biology and opening avenues for further research into various physiological and pathological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
While its primary target is myosin, blebbistatin indirectly affects cell adhesion by altering actomyosin contractility, which can impact talin-1 function. | ||||||
Dynamin Inhibitor II | 1119-97-7 | sc-203931 sc-203931A sc-203931B sc-203931C | 5 g 250 g 500 g 1 kg | $47.00 $84.00 $124.00 $198.00 | ||
This small molecule inhibitor has been reported to disrupt the interaction between talin-1 and integrin, leading to reduced cell adhesion. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
While not a direct talin-1 inhibitor, CK-666 is a compound that targets the actin cytoskeleton, which in turn can affect the activity of talin-1. | ||||||