Date published: 2025-10-15

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TAF II p100 Inhibitors

TAF II p100 inhibitors belong to a distinctive chemical class known for their capacity to modulate gene expression by targeting a key regulatory protein in cellular processes. The designation TAF II p100 refers to a specific transcriptional coactivator that plays a pivotal role in the assembly and activation of RNA polymerase II transcription complexes. These inhibitors are designed to interact with TAF II p100, disrupting its function and, consequently, influencing the intricate orchestration of gene transcription. The chemical class is characterized by compounds with unique structural features that enable them to bind selectively to TAF II p100, thereby impeding its ability to facilitate the transcriptional machinery. Researchers have been keenly exploring the molecular mechanisms underlying these inhibitors' mode of action to unravel the intricacies of transcriptional regulation within the cellular milieu.

TAF II p100 inhibitors, the emphasis lies on understanding the precise interactions at the molecular level, elucidating the structural determinants that confer binding specificity, and delineating the downstream consequences on gene expression patterns. This chemical class represents a promising avenue for investigations into the fundamental aspects of transcriptional control, shedding light on the intricate interplay between regulatory proteins and the transcriptional machinery. The development and characterization of TAF II p100 inhibitors contribute to the expanding toolkit available for researchers to manipulate gene expression patterns, offering insights into the underlying molecular processes that govern cellular function and potentially paving the way for novel approaches in the broader field of molecular biology.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$88.00
$200.00
13
(1)

Triptolide is known to inhibit transcription by targeting the XPB subunit of TFIIH, another transcription factor complex, which may indirectly affect TAF II p100 activity.

DRB

53-85-0sc-200581
sc-200581A
sc-200581B
sc-200581C
10 mg
50 mg
100 mg
250 mg
$42.00
$185.00
$310.00
$650.00
6
(1)

DRB is a kinase inhibitor that inhibits CDK9, a component of the positive transcription elongation factor b (P-TEFb), and can disrupt the transcription process affecting proteins like TAF II p100.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$260.00
$1029.00
26
(2)

α-Amanitin is a potent inhibitor of RNA polymerase II, which would indirectly reduce the functional necessity of TAF II p100 in the transcription initiation process.

Flavopiridol

146426-40-6sc-202157
sc-202157A
5 mg
25 mg
$78.00
$254.00
41
(3)

Flavopiridol inhibits cyclin-dependent kinases, including CDK9, which is essential for the phosphorylation of RNA polymerase II, thereby indirectly affecting TAF II p100's role in transcription initiation.

ICRF-193

21416-68-2sc-200889
sc-200889A
1 mg
5 mg
$330.00
$898.00
7
(1)

ICRF-193 is a topoisomerase II inhibitor that can disrupt DNA transcription, which would subsequently influence the function of transcription factors like TAF II p100.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Actinomycin D intercalates into DNA, inhibiting RNA polymerase movement and, consequently, transcription, indirectly affecting TAF II p100's function.

Cordycepin

73-03-0sc-203902
10 mg
$99.00
5
(1)

Cordycepin is an adenosine analog that terminates RNA synthesis prematurely, which could indirectly affect TAF II p100's role in transcription initiation.

Camptothecin

7689-03-4sc-200871
sc-200871A
sc-200871B
50 mg
250 mg
100 mg
$57.00
$182.00
$92.00
21
(2)

Camptothecin is a topoisomerase I inhibitor, which can lead to DNA damage responses that impair transcription, potentially impacting TAF II p100.

Leptomycin B

87081-35-4sc-358688
sc-358688A
sc-358688B
50 µg
500 µg
2.5 mg
$105.00
$408.00
$1224.00
35
(2)

Leptomycin B inhibits nuclear export of certain transcription factors, potentially altering the environment in which TAF II p100 operates.

Chelerythrine

34316-15-9sc-507380
100 mg
$540.00
(0)

Chelerythrine is a PKC inhibitor which can modulate signal transduction pathways and thus may indirectly influence TAF II p100's transcriptional regulation.