TAB182 Activators

Tankyrase 1 binding protein 1 (TNKS1BP1), also known as TAB182, is a protein that interacts with tankyrase 1, a poly(ADP-ribose) polymerase (PARP) enzyme. Tankyrases are involved in a variety of cellular processes, including regulation of telomere length, Wnt/β-catenin signaling, and vesicle trafficking. TNKS1BP1, as a binding partner, is implicated in the regulation and stabilization of tankyrase 1, influencing its activity and the downstream effects on cellular functions.

The interaction between TNKS1BP1 and tankyrase 1 is particularly important in the context of telomere maintenance. Tankyrase 1 has been shown to poly(ADP-ribosyl)ate TRF1, a component of the shelterin complex that protects telomeres, leading to its release from telomeres and thus affecting telomere length regulation. TNKS1BP1, by binding to tankyrase 1, may modulate this process and impact genomic stability.Furthermore, TNKS1BP1 has been found to associate with other proteins involved in DNA damage response and repair, suggesting a broader role in maintaining genomic integrity. The protein may also participate in signaling pathways that govern cell proliferation and survival, which are critical in development and cancer.