T2R13 Inhibitors
T2R13 inhibitors encompass a variety of compounds that share the ability to reduce the functional activity of the T2R13 receptor, which is involved in the detection of bitter compounds. These inhibitors operate through mechanisms that lead to the desensitization or downregulation of T2R13. Bitter compounds such as denatonium, quinine, and chloroquine are believed to initially stimulate T2R13 but can induce desensitization with sustained exposure. This desensitization occurs as a result of receptor internalization or the activation of negative feedback mechanisms that dampen receptor activity in the presence of prolonged stimuli.
Other compounds like capsaicin and lidocaine, although not directly interacting with T2R13, can modulate the sensitivity or signaling capacity of sensory neurons that express T2R13, thereby reducing its functional activity. Capsaicin achieves this through desensitization of sensory neurons, while lidocaine inhibits action potential generation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $32.00 $47.00 $141.00 $473.00 $921.00 | ||
Denatonium benzoate is a known bitter compound that can activate various bitter taste receptors including T2R13. By binding to T2R13, it triggers a G-protein-coupled receptor pathway resulting in the release of intracellular calcium. The increased intracellular calcium can lead to the desensitization of T2R13, reducing its sensitivity and functional activity in response to subsequent stimuli. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Quinine is an alkaloid that can bind to and activate bitter taste receptors. Its interaction with T2R13 elicits a signaling cascade involving the activation of phospholipase C, which in turn leads to the inhibition of T2R13 due to receptor desensitization after prolonged exposure, thus inhibiting its functional activity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine disrupts microtubule polymerization by binding to tubulin, which can indirectly affect GPCR trafficking to the cell surface. Since T2R13 is a GPCR, colchicine can inhibit its functional activity by reducing its presence on the cell surface, thereby decreasing its ability to respond to its ligands. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin binds to the vanilloid receptor subtype 1 (TRPV1). While not directly related to T2R13, prolonged exposure to capsaicin can lead to the desensitization of sensory neurons, potentially dampening the functional activity of co-expressed receptors such as T2R13 due to the overall reduced responsiveness of the sensory neurons. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to bind to and activate bitter taste receptors like T2R13. Binding of chloroquine to T2R13 leads to an increase in intracellular calcium, which can desensitize the receptor and inhibit its functional activity upon continuous exposure. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $51.00 $131.00 | ||
Lidocaine, a local anesthetic, can block voltage-gated sodium channels, which are vital for action potentials. If T2R13 is expressed in cells that also rely on such channels for activity, lidocaine could indirectly inhibit the functional activity of T2R13 by preventing the necessary electrical signaling. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $37.00 $56.00 $224.00 $1997.00 | ||
PTU is a compound known to have a bitter taste and can activate bitter taste receptors. It is inferred that PTU can bind to T2R13, leading to a signaling cascade that results in receptor desensitization, thereby reducing the receptor's functional activity. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper ions can bind to and activate several bitter taste receptors, potentially including T2R13. The activation of T2R13 by copper sulfate could lead to receptor desensitization due to sustained activation, resulting in a decreased functional activity of the receptor. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can activate bitter taste receptors including T2R13. The binding of caffeine to T2R13 may lead to a signaling cascade that ultimately results in receptor desensitization, inhibiting the receptor's functional activity. | ||||||
Saccharin | 81-07-2 | sc-212902 sc-212902A sc-212902B | 100 mg 1 g 10 g | $173.00 $235.00 $286.00 | ||
Saccharin is a synthetic sweetener that can also activate bitter taste receptors such as T2R13. Continuous activation of T2R13 by saccharin can result in receptor desensitization, leading to a decrease in the receptor's functional activity. | ||||||