T1R2 Inhibitors
The chemical class known as T1R2 inhibitors comprises a diverse group of compounds that exert their influence on sweet taste perception through intricate cellular signaling pathways. Rimonabant, a selective cannabinoid receptor type 1 (CB1) antagonist, indirectly inhibits T1R2 by modulating the endocannabinoid system. CB1 receptors, expressed in the brain and peripheral tissues, influence neural circuits related to taste perception, altering T1R2 function centrally. Genistein, an isoflavone, acts as an indirect inhibitor by interfering with tyrosine kinase signaling pathways, disrupting downstream events related to sweet taste perception mediated by T1R2. Compounds like SB-203580 and U0126, selective inhibitors of p38 MAPK and MEK1/2, respectively, indirectly influence T1R2 signaling by disrupting the MAPK pathway. These compounds alter intracellular signaling cascades associated with sweet taste perception, highlighting the complexity of taste signal transduction. These examples underscore the interconnectedness of metabolic processes and taste perception, providing insights into potential regulatory mechanisms governing sweet taste sensitivity.
Wortmannin and LY294002, inhibitors of phosphoinositide 3-kinase (PI3K), indirectly influence T1R2 signaling by disrupting downstream events related to sweet taste perception. The intricate interplay between PI3K signaling and T1R2 function highlights the complexity of taste signal transduction. Similarly, PD98059, a selective inhibitor of MEK, indirectly modulates T1R2 by disrupting the MAPK pathway, emphasizing the role of MAPK cascades in taste receptor cell function. AG-490, a Janus kinase 2 (JAK2) inhibitor, disrupts JAK-STAT pathways, indirectly influencing T1R2-mediated responses to sweet taste stimuli. AG-1478, a selective EGFR tyrosine kinase inhibitor, modulates T1R2 function by disrupting EGFR signaling pathways. SB-202190, another p38 MAPK inhibitor, indirectly influences T1R2 signaling by altering intracellular signaling cascades associated with sweet taste perception. Lastly, AZD5363, an AKT kinase inhibitor, indirectly modulates T1R2 function by disrupting the PI3K-AKT pathway, providing further insights into the complex regulatory networks governing sweet taste sensitivity. These T1R2 inhibitors collectively contribute to unraveling the intricate cellular signaling crossroads associated with sweet taste perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rimonabant | 168273-06-1 | sc-205491 sc-205491A | 5 mg 10 mg | $72.00 $160.00 | 15 | |
Rimonabant, a selective cannabinoid receptor type 1 (CB1) antagonist, indirectly inhibits T1R2 by modulating the endocannabinoid system. CB1 receptors are expressed in the brain and peripheral tissues, influencing neural circuits related to taste perception. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone, acts as an indirect inhibitor of T1R2 by interfering with tyrosine kinase signaling pathways. It inhibits various tyrosine kinases involved in cellular signal transduction, including the epidermal growth factor receptor (EGFR). | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB-203580, a selective inhibitor of p38 mitogen-activated protein kinase (MAPK), indirectly influences T1R2 signaling. p38 MAPK is involved in cellular stress responses, and its inhibition by SB-203580 affects downstream targets. In taste receptor cells, the modulation of p38 MAPK alters intracellular signaling pathways associated with sweet taste perception, indirectly impacting T1R2 function. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A-769662, an AMP-activated protein kinase (AMPK) activator, indirectly modulates T1R2 function through its impact on cellular energy homeostasis. By activating AMPK, A-769662 influences metabolic pathways and cellular energy status. This, in turn, can affect the responsiveness of taste receptor cells to sweet stimuli mediated by T1R2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, indirectly influences T1R2 signaling by disrupting downstream pathways. PI3K is a key enzyme in the insulin signaling pathway and is implicated in taste receptor cell function. Inhibition of PI3K by LY294002 alters intracellular signaling cascades related to sweet taste perception, indirectly affecting T1R2-mediated responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a fungal metabolite and PI3-kinase inhibitor, indirectly influences T1R2 signaling by disrupting the phosphoinositide 3-kinase (PI3K) pathway. PI3K is involved in various cellular processes, including taste receptor cell function. Wortmannin's inhibition of PI3K alters downstream signaling events related to sweet taste perception, indirectly impacting T1R2-mediated responses. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a selective inhibitor of mitogen-activated protein kinase kinase (MEK), indirectly modulates T1R2 function by disrupting the MAPK pathway. MEK is a critical component of the MAPK cascade, which plays a role in cellular signal transduction. Inhibition of MEK by PD98059 alters intracellular signaling cascades associated with sweet taste perception, indirectly influencing T1R2-mediated responses. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG-490 (Tyrphostin B42), a Janus kinase 2 (JAK2) inhibitor, indirectly influences T1R2 signaling by disrupting JAK-STAT pathways. JAK2 is involved in cytokine receptor signaling, and its inhibition by AG-490 alters downstream events in the JAK-STAT pathway related to taste receptor cell function. | ||||||
Tyrphostin AG 1478 | 175178-82-2 | sc-200613 sc-200613A | 5 mg 25 mg | $94.00 $413.00 | 16 | |
AG-1478, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, indirectly modulates T1R2 function by disrupting EGFR signaling pathways. EGFR is involved in cellular processes, including taste receptor cell function. Inhibition of EGFR by AG-1478 alters downstream signaling events related to sweet taste perception, indirectly influencing T1R2-mediated responses. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB-202190, a selective inhibitor of p38 mitogen-activated protein kinase (MAPK), indirectly influences T1R2 signaling. p38 MAPK is implicated in cellular stress responses, and its inhibition by SB-202190 affects downstream targets. In taste receptor cells, the modulation of p38 MAPK alters intracellular signaling pathways associated with sweet taste perception, indirectly impacting T1R2 function. | ||||||