syntenin-1 Activators
Syntenin-1 activators represent a diverse array of chemicals that intricately modulate the activity of syntenin-1, a multifunctional scaffold protein involved in various cellular processes, including cell adhesion, migration, signaling, and vesicular trafficking. These activators, either direct or indirect, play pivotal roles in regulating syntenin-1 expression and function, contributing to the orchestration of cellular events. Direct activators such as PP2, Dasatinib, and Genistein impact syntenin-1 by targeting specific kinases. PP2, a Src inhibitor, influences the FAK/PI3K/Akt pathway, indirectly activating syntenin-1 and contributing to cell adhesion and migration. Dasatinib, another Src family kinase inhibitor, affects similar downstream pathways, amplifying syntenin-1's involvement in cellular processes. Genistein, through tyrosine kinase inhibition, impacts MAPK signaling, elevating syntenin-1 levels and influencing cell adhesion and vesicular trafficking.
Indirect activators like LY294002, Wortmannin, and A-419259 modulate syntenin-1 by inhibiting PI3K and PDK1. LY294002 and Wortmannin inhibit PI3K, influencing the Akt/mTOR pathway and contributing to increased syntenin-1 expression. A-419259, a PDK1 inhibitor, impacts the Akt/mTOR pathway, amplifying syntenin-1's involvement in intracellular signaling and exosome biogenesis. Other indirect activators, including SP600125, AG490, and PD98059, influence syntenin-1 through JNK, JAK2, and MEK inhibition, respectively. These inhibitors impact pathways such as MAPK and STAT3, enhancing syntenin-1 expression and function in cellular processes like vesicular trafficking and signaling. In summary, syntenin-1 activators comprise a comprehensive collection of chemicals that offer insights into the intricate regulatory network governing syntenin-1's involvement in cellular dynamics. Whether through direct kinase modulation or indirect signaling pathway regulation, these activators contribute to understanding syntenin-1's multifaceted roles in cellular physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 inhibits Src kinase, which indirectly activates syntenin-1. Src inhibition influences the FAK/PI3K/Akt pathway, leading to enhanced syntenin-1 expression and its involvement in cell adhesion, migration, and signal transduction. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein indirectly activates syntenin-1 by inhibiting tyrosine kinases. Tyrosine kinase inhibition influences downstream pathways such as MAPK, contributing to elevated syntenin-1 levels and its participation in cell adhesion and vesicular trafficking. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib inhibits Src family kinases, indirectly activating syntenin-1. Src inhibition affects downstream signaling pathways, including FAK/PI3K/Akt, contributing to elevated syntenin-1 expression and its roles in cell adhesion, migration, and signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits p38 MAPK, indirectly activating syntenin-1. p38 MAPK inhibition influences cellular processes, including vesicular trafficking, contributing to increased syntenin-1 expression and its involvement in intracellular signaling and membrane dynamics. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG490 inhibits JAK2, indirectly activating syntenin-1. JAK2 inhibition influences the STAT3 pathway, leading to enhanced syntenin-1 expression and its roles in intracellular signaling, membrane dynamics, and exosome biogenesis. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 inhibits MEK, indirectly activating syntenin-1. MEK inhibition impacts the ERK/MAPK pathway, contributing to increased syntenin-1 expression and its involvement in intracellular signaling, membrane dynamics, and vesicular trafficking. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, indirectly activating syntenin-1. JNK inhibition influences cellular processes, including vesicular trafficking, contributing to increased syntenin-1 expression and its roles in intracellular signaling and membrane dynamics. | ||||||
A 419259 trihydrochloride | 1435934-25-0 | sc-361094 | 5 mg | $213.00 | 6 | |
A-419259 inhibits PDK1, indirectly activating syntenin-1. PDK1 inhibition influences the Akt/mTOR pathway, contributing to increased syntenin-1 expression and its involvement in intracellular signaling, membrane dynamics, and exosome biogenesis. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
JSH-23 inhibits NF-κB, indirectly activating syntenin-1. NF-κB inhibition influences cellular processes, including vesicular trafficking, contributing to increased syntenin-1 expression and its roles in intracellular signaling and membrane dynamics. | ||||||