Svs7 Inhibitors

The Svs7 Inhibitors chemical class comprises a diverse set of compounds targeting various aspects of lysosomal function and related cellular processes crucial for Svs7 activity. Bafilomycin A1 and Concanamycin A inhibit Svs7 by disrupting lysosomal acidification through V-ATPase inhibition. Chloroquine raises lysosomal pH, impairing Svs7 function indirectly. Leupeptin, Pepstatin A, and E-64 interfere with lysosomal protease activity, preventing Svs7 degradation. Monensin disrupts ion gradients in lysosomal membranes, impacting Svs7 activity. Resveratrol modulates autophagy, indirectly influencing Svs7. Rapamycin inhibits Svs7 through mTOR inhibition, and Ebselen acts as a redox modulator, affecting lysosomal function. Niclosamide modulates AMPK, and Nilotinib targets c-Abl kinase, both indirectly influencing Svs7 activity. This diverse class collectively interferes with multiple cellular processes linked to lysosomal function and Svs7 activity, providing potential strategies for modulation in cellular contexts.